{"product_id":"abcam-ab84706","title":"Abcam, ab84706, Anti-KPNA3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal KPNA3 antibody. Suitable for IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human KPNA3 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human KPNA3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O00505\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAntibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKPNA3 also known as importin subunit alpha-4 is a protein that mediates the nuclear import of proteins by recognizing nuclear localization signals. Its molecular mass is approximately 58 kDa. KPNA3 is present in various tissues including brain liver and heart which suggests its importance in cellular functions across these organs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKPNA3 facilitates the transport of proteins into the nucleus serving as an adapter between cargo proteins and the importin beta subunit. KPNA3 is part of the importin complex which is important for nucleocytoplasmic transport. The efficiency of nuclear protein import depends on KPNA3's ability to bind and release cargo proteins effectively.\u003cbr\u003e\nPathways\u003cbr\u003e\nKPNA3 integrates into the nucleocytoplasmic transport pathways and interacts significantly with importin beta. It participates in the regulation of gene expression by ensuring the proper localization of transcription factors. The protein is also connected to other members of the importin family such as KPNA1 and KPNA2 which similarly serve roles in nuclear import pathways.\u003cbr\u003e\nKPNA3 has links to various conditions such as viral infections and cancer. The protein can interact with viral proteins to facilitate the transport of viral genomes into the nucleus. In cancer KPNA3 expression levels often correlate with the deregulation of nuclear import pathways influencing tumor progression. KPNA3's interactions with proteins like p53 highlight its relevance in understanding disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848623444137,"sku":"ab84706","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab84706","provider":"Iright","version":"1.0","type":"link"}