{"product_id":"abcam-ab84763","title":"Abcam, ab84763, Recombinant Human Tau412 protein","description":"\u003cp\u003eSize: 20µg \/ 50µg\u003cbr\u003e\nRecombinant Human Tau412 protein is a Human Full Length protein, in the 1 to 412 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% Densitometry,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P10636,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00174% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nIsoform Tau E\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTau412 also known as Tau is a microtubule-associated protein that plays a role in stabilizing microtubules. It has a molecular weight of approximately 55-62 kDa depending on its isoform. Tau is abundantly expressed in neurons but can also be found in other tissues like the heart and kidneys. Its mechanical function involves interaction with tubulin which is important for maintaining the structure of axons. Tau has six isoforms as a result of alternative splicing from a single gene located on chromosome 17.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTau412 helps in the assembly and stabilization of microtubules which are important for axonal transport and neuronal function. It is not part of a larger protein complex but interacts with several microtubule and cytoskeleton proteins. Tau phosphorylation regulates its binding with microtubules affecting microtubule stability. Imbalance in Tau phosphorylation states can disrupt cellular processes and result in aggregation.\u003cbr\u003e\nPathways\u003cbr\u003e\nTau412 is involved in the microtubule disassembly and assembly pathways. It interacts with proteins like glycogen synthase kinase-3 beta (GSK-3β) and CDK5 which phosphorylate Tau and regulate its interaction with microtubules. Through these pathways Tau affects cellular transport and signaling mechanisms essential for neuronal function and survival.\u003cbr\u003e\nMutations or misregulation of Tau412 are linked to neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. In Alzheimer's disease hyperphosphorylated Tau forms neurofibrillary tangles which are hallmarks of the disease along with amyloid-beta plaques. Tauopathies a group of disorders characterized by accumulations of Tau often involve interactions with amyloid-beta and other proteins such as apolipoprotein E (ApoE) which influence disease pathology and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843949678761,"sku":"ab84763","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab84763","provider":"Iright","version":"1.0","type":"link"}