{"product_id":"abcam-ab87663","title":"Abcam, ab87663, Anti-GATAD2A antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal GATAD2A antibody. Suitable for IHC-P, IP, WB, ICC\/IF and reacts with Mouse, Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human Transcriptional repressor p66-alpha aa 550 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Transcriptional repressor p66-alpha aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q86YP4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe GATAD2A gene encodes a protein also known as P66-alpha weighing approximately 65 kDa. This protein is largely expressed in the nucleus of eukaryotic cells. GATAD2A interacts with other proteins to regulate transcription and is part of the transcription repression complexes. Its expression is seen widely across various tissues indicating its broad regulatory role in gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGATAD2A functions by interacting with multiple factors to form the nucleosome remodeling and deacetylase (NuRD) complex. This complex is critical in modifying chromatin to control gene transcription. GATAD2A assists in recruiting this complex to specific genomic regions helping to repress or activate gene expression depending on the cellular context. GATAD2A's involvement in chromatin remodeling highlights its important role in cell cycle regulation and development.\u003cbr\u003e\nPathways\u003cbr\u003e\nGATAD2A participates in epigenetic regulation pathways and the cellular differentiation process. It cooperates with other NuRD complex proteins like MBD2 and CHD4 which play roles in DNA methylation and histone modification. Through these interactions GATAD2A helps in maintaining the balance between gene repression and activation which is necessary for various cellular processes including differentiation and proliferation.\u003cbr\u003e\nGATAD2A shows associations with neurodevelopmental disorders and certain cancer forms. It has been noted to interact with proteins involved in these conditions such as transcriptional repressors and factors like CDK11 suggesting its role in disease progression. Abnormal GATAD2A function or expression can lead to disrupted chromatin dynamics potentially contributing to the pathogenesis of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850099019945,"sku":"ab87663","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab87663","provider":"Iright","version":"1.0","type":"link"}