{"product_id":"abcam-ab87844","title":"Abcam, ab87844, Anti-ATF7 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ATF7 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATF7 aa 400 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ATF7 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P17544\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Affinity purified using an epitope specific to ATF7 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATF7 (activating transcription factor 7) is a transcription factor that belongs to the ATF\/CREB family. It has alternative names such as ATFa and B-ATF. Mechanically ATF7 regulates transcription by binding to cyclic AMP response elements (CRE) in DNA. This protein has a mass of approximately 55 kDa. ATF7 is expressed in various tissues throughout the body including the brain liver and spleen supporting its involvement in multiple physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATF7 functions in cellular stress responses and cell differentiation. It often forms a complex with other transcription factors to exert its effects on gene expression. ATF7 is known to influence the expression of genes involved in stress response pathways and apoptosis. By regulating these genes ATF7 plays a role in how cells react to environmental changes and maintain homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nATF7 is involved in significant signaling pathways such as the MAPK and JNK pathways. These pathways are important for transmitting signals from the cell surface to the nucleus affecting gene expression. ATF7 interacts with proteins such as c-Jun and ATF2 within these pathways facilitating cellular responses to stress and growth signals.\u003cbr\u003e\nATF7 has been linked to certain cancers and neurodegenerative diseases. Abnormal expression or mutation of ATF7 can contribute to the progression of cancer possibly through its interaction with proteins like c-Myc. In neurodegenerative conditions ATF7 might play a role in neuronal cell death potentially in connection with proteins involved in stress signaling such as p53. Understanding the role of ATF7 in these disorders may provide insight into new therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853980487849,"sku":"ab87844","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab87844","provider":"Iright","version":"1.0","type":"link"}