{"product_id":"abcam-ab88612","title":"Abcam, ab88612, Anti-TRAF4 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal TRAF4 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRAF4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human TRAF4.Q9BUZ4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRAF4 also known as Tumor Necrosis Factor Receptor-Associated Factor 4 is a scaffold protein with a molecular weight of approximately 55 kDa. TRAF4 interacts with a variety of intracellular signaling molecules influencing signal transduction. It is expressed prominently in epithelial cells and the respiratory tract reflecting its involvement in tissue homeostasis and cell communication. The protein contains a conserved RING finger domain a novel zinc finger TRAF-type domain and a coiled-coil region which are essential for its function in protein-protein interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRAF4 participates in the regulation of immune responses and development of epithelial tissues. This protein modulates signaling pathways by promoting or inhibiting the activation of transcription factors including NF-κB and AP-1 which are critical for the immune system's function. TRAF4 associates with various adapter proteins forming signaling complexes that influence cellular outcomes during immune responses. It also plays a role in the development and integrity of the respiratory epithelium highlighting its importance in maintaining epithelial barrier functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRAF4 integrates into the TNF receptor signaling pathway and the TGF-beta signaling pathway. In the TNF receptor pathway TRAF4 interacts with other TRAF family members mediating responses to inflammatory cytokines and regulating apoptosis. Within the TGF-beta pathway TRAF4 modulates signal transduction involving Smad proteins impacting cellular growth and differentiation. The protein's role within these pathways highlights its capacity to influence both immune responses and tissue homeostasis.\u003cbr\u003e\nTRAF4 has associations with cancer progression and chronic inflammatory diseases. Altered expression levels of TRAF4 can contribute to tumorigenesis by affecting cell survival and proliferation involving interaction with proteins like NF-κB and TGF-beta receptors. In chronic inflammatory diseases TRAF4's dysregulation can exacerbate inflammation through pathways that involve interactions with cytokines and other TRAF family proteins. TRAF4 represents a potential target for therapeutic intervention aiming to modulate immune responses and ameliorate disease symptoms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852260102313,"sku":"ab88612","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab88612","provider":"Iright","version":"1.0","type":"link"}