{"product_id":"abcam-ab89414","title":"Abcam, ab89414, Anti-Cathepsin E antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal Cathepsin E antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Cathepsin E aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Cathepsin E aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P14091\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCathepsin E also known as CATE is an aspartic protease with a molecular mass of approximately 40 kDa. It functions within the cell to perform endopeptidase activity meaning it cleaves peptide bonds within proteins. Cathepsin E shows expression in the gastric mucosa and is prevalent in immune-related tissues such as the spleen and thymus. This enzyme operates optimally at acidic pH levels specializing in the breakdown of proteins in lysosomes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCathepsin E plays a role in protein degradation and processing within lysosomal compartments. It associates with lysosomal and endosomal pathways participating actively in immune response regulation. Cathepsin E does not form part of a larger complex; however its activity can influence the function of other immune-related proteins by modifying antigen presentation.\u003cbr\u003e\nPathways\u003cbr\u003e\nCathepsin E engages with the major histocompatibility complex (MHC) class II pathway. This involvement assists in the processing of antigenic peptides for presentation to CD4+ T-cells connecting Cathepsin E to adaptive immune responses. Additionally it interacts with proteins such as HLA-DM which modulates the peptide loading on MHC class II molecules during immune surveillance.\u003cbr\u003e\nResearchers link Cathepsin E to gastric cancer and Alzheimer's disease. In gastric cancer Cathepsin E overexpression can alter tumor microenvironments impacting disease progression. Furthermore in Alzheimer's disease Cathepsin E's activity correlates with amyloid precursor protein (APP) metabolism which can influence the accumulation of amyloid-beta plaques a hallmark of the disease process.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852258463913,"sku":"ab89414","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab89414","provider":"Iright","version":"1.0","type":"link"}