{"product_id":"abcam-ab92506","title":"Abcam, ab92506, Anti-STAT1 alpha antibody [EPYR2154]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal STAT1 antibody. Suitable for ChIC\/CUT\u0026amp;RUN-seq, IP, WB, IHC-P and reacts with Human, Mouse samples. Cited in 32 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPYR2154,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:WB, IP, IHC-P, ChIC\/CUT\u0026amp;RUN-seqSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Based on Blast results using the immunogen sequence, this antibody should recognise the alpha but not the beta form (only 30% homology) of Stat1.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSTAT1 alpha also known as Signal Transducer and Activator of Transcription 1-alpha is a protein with a mass of approximately 91 kDa. It operates in the cell nucleus and cytoplasm to mediate signal transduction and activation of transcription. STAT1 alpha does this by dimerizing following phosphorylation enabling its nuclear translocation. It is broadly expressed in many tissues including immune cells. This expression plays an important role in response to cytokines and other signaling molecules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSTAT1 alpha functions as a critical component of the interferon signaling pathway. It is part of a transcription factor complex that regulates the expression of genes involved in cell proliferation differentiation and immune response. STAT1 alpha mediates its effects by forming homo- or heterodimers with related proteins and binding to specific DNA sequences. This interaction facilitates the transcription of genes necessary for innate and adaptive immunity highlighting its fundamental role in host defense mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nSTAT1 alpha participates in the JAK-STAT signaling pathway and interferon signaling pathways. It interacts with Janus kinases (JAKs) after cytokine stimulation resulting in its phosphorylation and dimerization. This pathway links it with other STAT family members such as STAT2 and STAT3 to regulate gene expression. These pathways ensure proper immune function and cell growth control indicating STAT1 alpha's essential role in various cellular processes.\u003cbr\u003e\nSTAT1 alpha is associated with autoimmune diseases and certain cancers. Its malfunction can result in inadequate immune responses or excessive inflammation. In some cancers altered STAT1 alpha activity contributes to unchecked cell proliferation. STAT1 alpha interacts with various proteins such as IFNGR1 and IRF1 in these disease states affecting their signaling pathways. Its dysregulation indicates a potential target for therapeutic intervention in these disorders making it of interest for medical research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844129018025,"sku":"ab92506","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab92506","provider":"Iright","version":"1.0","type":"link"}