{"product_id":"abcam-ab92519","title":"Abcam, ab92519, Anti-Aldehyde Oxidase antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Aldehyde Oxidase antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human AOX1 aa 500-600.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human AOX1 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.Q06278\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab92519 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAldehyde Oxidase (AOX) also known by alternate names such as aldehyde oxidoreductase is a cytosolic enzyme with a molecular mass of approximately 150 kDa. This enzyme expresses itself across various tissues including the liver lungs and other organs where it catalyzes the oxidation of aldehydes into acids. AOX requires molybdenum iron and flavin adenine dinucleotide (FAD) as cofactors enabling its activity in the detoxification of xenobiotic and endogenous aldehydes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAldehyde oxidation involves processes that transform aldehydes into less reactive carboxylic acids aiding cellular regulatory functions. AOX plays a role within the molybdo-flavoenzyme complex. This complex participates in metabolic reactions that help maintain homeostasis within cells and manage oxidative stress. Its presence in the liver highlights its role in drug metabolism where it manages the oxidation of a variety of substances and reduces metabolic burden.\u003cbr\u003e\nPathways\u003cbr\u003e\nOne of the significant roles of aldehyde oxidase lies within the purine metabolism pathway. It helps convert purines into uric acid which supports the final steps of purine degradation. This enzyme shares pathways with xanthine oxidase another critical enzyme in purine catabolism. Additionally AOX participates in the biosynthesis and breakdown of several drugs and xenobiotics in the drug metabolism pathway exhibiting similarity to cytochrome P450 enzymes in its substrate preferences.\u003cbr\u003e\nAldehyde oxidase's dysfunction links to disorders like liver damage and certain neurological conditions due to its role in oxidative stress management. Impaired activity of AOX can lead to toxic aldehyde accumulation creating a harmful cellular environment that exacerbates liver damage. Furthermore AOX's connection with other enzymes such as xanthine oxidase relates it to conditions like gout where altered purine metabolism leads to excessive uric acid production and crystal formation in joints.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854363545769,"sku":"ab92519","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab92519","provider":"Iright","version":"1.0","type":"link"}