{"product_id":"abcam-ab92862","title":"Abcam, ab92862, Recombinant Human Ephrin B2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human Ephrin B2 protein is a Human Fragment protein, in the 1 to 227 aa range, expressed in HEK 293 cells, with \u0026gt;99%, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;99% SDS-PAGE,\u003cbr\u003e\nExpression system:HEK 293 cells,\u003cbr\u003e\nTags:Fc tag C-Terminus His tag C-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P52799,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nReconstitution:Please add 20ul of PBS to make 0.5mg\/ml,\u003cbr\u003e\nStorage buffer:pH: 7.4Constituents: PBS\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAfter reconstitution, store in working aliquots at -80ºC.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEphrin B2 also called EFNB2 or ephrin-B2 is a transmembrane protein that plays important roles in cell signaling. The protein weighs approximately 37 kDa and it is expressed in various tissues like endothelial cells and neuronal tissues. Ephrin B2 binds to Eph receptors which are a part of the largest family of receptor tyrosine kinases. This interaction facilitates bidirectional signaling necessary for mediating cell communication.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEphrin-B2 serves as critical mediator for vascular development and nervous system maturation. It is an important player in angiogenesis where it functions through interaction with EphB receptors to regulate blood vessel formation and remodeling. Ephrin-B2 part of the larger ephrin family often acts in concert with other ephrins and Eph receptors to form signaling complexes that coordinate cell positioning and tissue architecture.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe action of ephrin-B2 integrates into the Eph\/ephrin signaling pathway and the VEGF signaling pathway. These pathways are important for cellular guidance and migration particularly in developing tissues. Ephrin B2's interaction with proteins like VEGF and its receptors emphasizes its role in angiogenic processes. Furthermore Ephrin-B2 interacts with other Eph receptor proteins to modulate cellular responses essential for proper vascular and neural functions.\u003cbr\u003e\nEphrin-B2's dysregulation associates with cancer and cardiovascular conditions. High expression of ephrin-B2 has been observed in tumor angiogenesis linking it to cancer progression through interactions with VEGF. Abnormal ephrin-B2 signaling may also relate to atherosclerosis involving disrupted endothelial cell function. These associations reveal ephrin-B2's potential as a therapeutic target for conditions involving aberrant vascular and cellular dynamics.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843893285033,"sku":"ab92862","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab92862","provider":"Iright","version":"1.0","type":"link"}