{"product_id":"abcam-ab92932","title":"Abcam, ab92932, Recombinant Human ENSA protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human ENSA protein is a Human Full Length protein, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:O43768,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nENSA also known as alpha-endosulfine is a protein with a mass of approximately 13 kDa. ENSA is part of the endosulfine family and finds expression in various tissues including the brain and pancreas. This protein primarily acts as an endogenous ligand for sulfonylurea receptor and has a role in regulating potassium channels. Its structural and functional characteristics highlight its importance in cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nENSA functions as a modulator of protein phosphatase 2A (PP2A) a critical enzyme in controlling cell growth and division. ENSA by inhibiting the catalytic activity of PP2A influences key regulatory mechanisms in cells. It also interacts with ARPP-19 a protein that enhances its inhibitory action contributing to the regulation of cellular processes such as mitosis and signal transduction.\u003cbr\u003e\nPathways\u003cbr\u003e\nENSA plays a significant role in the mTOR signaling pathway a major regulator of cell growth metabolism and survival. In this pathway ENSA interacts with various proteins including the mTOR itself to modulate the phosphorylation state of downstream targets affecting cellular responses to nutrient availability. Additionally ENSA is involved in the regulation of glucose metabolism through its interaction in the AMPK signaling pathway contributing to energy homeostasis in cells.\u003cbr\u003e\nENSA demonstrates a connection to metabolic disorders such as type 2 diabetes by modulating insulin secretion and action. ENSA impacts the glucose regulatory processes through its association with proteins like the sulfonylurea receptor important in insulin release from pancreatic beta cells. Moreover ENSA's involvement in the dysregulation of cell growth pathways relates to certain cancers indicating its potential role in tumorigenesis through its interaction with PP2A and associated signaling components.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843861991593,"sku":"ab92932","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab92932","provider":"Iright","version":"1.0","type":"link"}