{"product_id":"abcam-ab9383","title":"Abcam, ab9383, Anti-Cytokeratin 10 + 13 antibody [DE-K13]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal Cytokeratin 10 antibody. Suitable for IHC-Fr and reacts with Zebrafish samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human KRT10.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:DE-K13,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Zebrafish,\u003cbr\u003e\nApplications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Full Length Protein corresponding to Human KRT10. The exact immunogen used to generate this antibody is proprietary information.P13645,\u003cbr\u003e\nSpecificity:This antibody reacts with cytokeratin 10 and 13 in fixed cells and frozen tissue, but exclusively with cytokeratin 13 in formalin fixed paraffin embedded tissue.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytokeratin 10 and 13 also known as CK10 and CK13 are intermediate filament proteins part of the keratin family. Cytokeratin 10 has a molecular mass of approximately 59 kDa while cytokeratin 13 weighs about 53 kDa. Expression of these proteins occurs mainly in the stratified epithelium like that found in the epidermis and certain mucosal tissues. Their mechanical role includes maintaining structural integrity and providing resilience to epithelial cells against mechanical stress.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCytokeratin 10 and 13 play important roles in the differentiation and development of epithelial tissues. As components of the cytoskeletal network they aid in cell adhesion migration and intracellular signaling. These proteins integrate into a complex of intermediate filaments that support cellular architecture collaborating with other cytokeratins to sustain cellular framework.\u003cbr\u003e\nPathways\u003cbr\u003e\nCytokeratin 10 and 13 participate in the keratinization process essential for skin homeostasis. They are integral to the epidermal differentiation complex which includes interactions with proteins like loricrin and filaggrin. These pathways ensure proper formation of the skin barrier and prevent water loss maintaining skin's protective function.\u003cbr\u003e\nCytokeratin 10 and 13 are associated with conditions such as Ichthyosis with confetti and oral cancer. Altered expression or mutations can lead to disruptions in epithelial differentiation contributing to disease pathogenesis. Their involvement with proteins like p63 and other keratins links them to hereditary skin disorders where impaired regulation of the keratinocyte life cycle manifests as clinical symptoms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860477563049,"sku":"ab9383","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab9383","provider":"Iright","version":"1.0","type":"link"}