{"product_id":"abcam-ab93884","title":"Abcam, ab93884, Anti-Bcl2 alpha antibody [SP66] - N-terminal","description":"\u003cp\u003eSize: 100µL \/ 500µL \/ 1mL\u003cbr\u003e\nAnti-Bcl2 alpha antibody [SP66] - N-terminal (ab93884) is a rabbit monoclonal antibody detecting Bcl2 alpha in  IHC-P . Suitable for  Human . - Biophysical QC for unrivalled batch-batch consistency - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:SP66,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Bcl2 alpha antibody [SP66] - N-terminal (ab93884) is a rabbit recombinant monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.\u003cbr\u003e\nCollaboration\u003cbr\u003e\nAnti-Bcl2 alpha [SP66] - N-terminal (ab93884) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC).\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [SP66] also available for your convenience: ab93884, Carrier free -\u003cbr\u003e\nab236221\u003cbr\u003e\n, ab279431\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Purification notes-Purified from TCS by protein A\/G., Storage buffer-pH: 7.6Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBcl2 alpha also known as B-cell lymphoma 2 is a protein with a molecular mass of approximately 26 kDa. This protein plays an important role mechanically as a regulator of apoptosis actively inhibiting cell death in various cell types. Expressed in cells of hematopoietic origin Bcl2 alpha localizes mainly within the outer mitochondrial membrane nuclear envelope and endoplasmic reticulum. The protein's prominent function contributes to balancing cell survival and death making it significant in cellular homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBcl2 alpha controls the intrinsic pathway of apoptosis. It is a part of the Bcl-2 family which consists of proteins that either promote or inhibit apoptosis. Bcl2 alpha interacts with other Bcl-2 family members forming either pro-apoptotic or anti-apoptotic complexes. It ensures cell survival by preventing the release of cytochrome c from mitochondria and interacting with pro-apoptotic proteins like Bax and Bak. This interaction obstructs the activation of caspase enzymes which are critical in the execution of apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nBcl2 alpha functions within the apoptotic and mitochondrial pathways. In the apoptotic pathway Bcl2 alpha plays an anti-apoptotic role by modulating the activity of pro-apoptotic proteins mainly through its interactions with Bax and Bak. Within the mitochondrial pathway Bcl2 alpha affects the permeability of the mitochondrial membrane thereby influencing the release of factors that initiate caspase activation. These pathways involve interconnected roles with other key proteins these roles affecting processes such as cell cycle regulation and response to cellular stress.\u003cbr\u003e\nBcl2 alpha is notably associated with certain cancers and neurodegenerative diseases. In cancers like lymphoma Bcl2 alpha is often overexpressed which leads to increased cell survival and resistance to apoptosis therefore contributing to tumor progression. The protein is also linked to neurodegenerative diseases where it may influence neuronal survival. Connections with proteins like myc in cancers and others in neurological contexts further highlight the importance of Bcl2 alpha in these disorders. Understanding its role offers potential therapeutic targets for treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850375221417,"sku":"ab93884","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab93884","provider":"Iright","version":"1.0","type":"link"}