{"product_id":"abcam-ab94806","title":"Abcam, ab94806, Anti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3] (ab94806) is a mouse monoclonal antibody detecting Respiratory Syncytial Virus Nucleoprotein in  IP, ICC\/IF, ELISA . Suitable for  Respiratory syncytial virus . - Over 10 publications - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RSV1C3,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Respiratory syncytial virus,\u003cbr\u003e\nApplications:ELISA, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody has broad specificity for Human Respiratory syncytial virus of both sub groups A and B.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Respiratory Syncytial Virus Nucleoprotein antibody [RSV1C3] (ab94806) is a mouse monoclonal antibody and is validated for use in Immunoprecipitation (IP), Immunocytochemistry\/immunofluorescence (ICC\/IF), ELISA in Respiratory syncytial virus samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Respiratory Syncytial Virus Nucleoprotein [RSV1C3] (ab94806) was first used in a scientific publication in 2010 and has been cited over 10 times in peer-reviewed journals.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRespiratory Syncytial Virus Nucleoprotein (RSV N protein) plays a central mechanical role in the replication and transcription of the RSV genome. It binds single-stranded RNA acting as a scaffold for the virus's RNA synthesis. The nucleocapsid protein another name for RSV N protein has a molecular mass of approximately 45 kilodaltons. It is expressed in cells infected by the RSV notably within the cytoplasm forming a protective helix around the viral RNA genome.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWithin the context of viral infection and replication RSV N protein is essential for packaging and protecting the viral RNA genome. It forms part of a complex with the phosphoprotein (P protein) and the large polymerase protein (L protein) to facilitate RNA replication and transcription. This complex ensures the stability and integrity of the viral genome allowing the virus to efficiently replicate and produce infectious particles. Therefore the nucleoprotein strongly influences the life cycle of the virus.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe RSV N protein functional capacity is pivotal within the viral RNA transcription and replication pathways. It closely interacts with the phosphoprotein P enhancing the activity of the viral RNA-dependent RNA polymerase complex. This interaction synergistically ties into the virus's replication pathway ensuring the production of viral RNAs. The N protein also coordinates with M2-1 protein in regulating mRNA synthesis and RNA processing reflecting its comprehensive involvement in essential viral pathways.\u003cbr\u003e\nThe involvement of RSV N protein connects strongly to respiratory tract infections particularly in infants and the elderly. RSV infection often leads to bronchiolitis and pneumonia where the N protein plays an important role in propagating the disease. Its interaction with the fusion glycoprotein (F protein) facilitates virus assembly and release which enhances viral spread and subsequent infection severity. Researchers often focus on these proteins when developing therapeutics targeting RSV-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855402619049,"sku":"ab94806","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab94806","provider":"Iright","version":"1.0","type":"link"}