{"product_id":"abcam-ab94968","title":"Abcam, ab94968, Anti-Respiratory Syncytial Virus Fusion (F) Glycoprotein antibody [RSV5A6]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nAnti-Respiratory Syncytial Virus Fusion (F) Glycoprotein antibody [RSV5A6] (ab94968) is a mouse monoclonal antibody detecting Respiratory Syncytial Virus Fusion (F) Glycoprotein in  Western Blot, IHC-P, IHC-Fr, ICC\/IF, ELISA . - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:RSV5A6,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Respiratory syncytial virus,\u003cbr\u003e\nApplications:WB, IHC-Fr, ICC\/IF, IHC-P, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Cell preparation containing F protein. The exact immunogen used to generate this antibody is proprietary information.P03420\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Respiratory Syncytial Virus Fusion (F) Glycoprotein antibody [RSV5A6] (ab94968) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry\/immunofluorescence (ICC\/IF), ELISA in Respiratory syncytial virus samples.\u003cbr\u003e\nWhat is the molecular weight of Respiratory Syncytial Virus Fusion (F) Glycoprotein?\u003cbr\u003e\nAnti-Respiratory Syncytial Virus Fusion (F) Glycoprotein [RSV5A6] (ab94968) specifically detects a band for Respiratory Syncytial Virus Fusion (F) Glycoprotein (UniProt: P03420) at a molecular weight of 63kDa.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azide Constituents: 99.98% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein commonly referred to as the F protein is an important protein weighing approximately 70 kDa. This glycoprotein is expressed on the surface of the RSV virus. Its primary mechanical function involves mediating the fusion of the viral envelope with the host cell membrane a critical step in viral entry. By facilitating this fusion process the F protein ensures that the RSV genome gains access to the host cell cytoplasm for replication. Alternate designations for this protein include the fusion (F) protein and anti-RSV F protein reflecting its important role in RSV infectivity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe fusion facilitation of the Respiratory Syncytial Virus involves direct interaction with the host cell membrane allowing viral entry. The F protein is a part of the larger RSV virion structure but does not form complexes with other proteins within the virus. Complete understanding of its structure-activity relationship enhances the development of therapeutic agents targeting viral entry. It represents a direct target for antiviral strategies aiming to inhibit the initial stages of infection reducing the spread and impact of RSV infection.\u003cbr\u003e\nPathways\u003cbr\u003e\nKnowledge about the Respiratory Syncytial Virus F protein highlights its involvement in viral entry and fusion pathways. The F protein plays an essential role in the membrane fusion pathway which is a common mechanism among enveloped viruses. It interfaces with cellular proteins during the virus's attempt to penetrate the host cell. Understanding these interactions aids in the larger framework of viral-host interplay contributing to potential therapeutic pathways like inhibitor development.\u003cbr\u003e\nRSV infection relates the fusion protein directly to respiratory tract illnesses such as bronchiolitis and pneumonia. It serves as an important target for preventing the exacerbation of these conditions especially in infants and the elderly. The protein's role in facilitating viral entry makes it an attractive candidate for vaccine development further supported by the related G protein of RSV in eliciting the immune response. These associations highlight the importance of the F protein not only in understanding RSV pathology but also in devising strategies for disease prevention and treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848524026025,"sku":"ab94968","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab94968","provider":"Iright","version":"1.0","type":"link"}