{"product_id":"abcam-ab95175","title":"Abcam, ab95175, Anti-IMPACT antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal IMPACT antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human IMPACT aa 250 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human IMPACT aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9P2X3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab95175 was affinity purified using an epitope specific to IMPACT immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIMPACT also known as Impact homolog or CI-68 is a protein that has around 33 kDa molecular weight. It is well-conserved across species and has significant expression in the brain. The protein can bind to ribosomes potentially influencing translation regulation. IMPACT can modulate translation initiation and is detected in other tissues but with lesser intensity than in the brain.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe regulation of translation initiation is a critical function that IMPACT performs. It is thought to affect the cellular stress response by interacting with components of the translation machinery. IMPACT does not function as part of a large complex but influences the availability of translation factors. This influence is essential in neurons where it helps them survive under various environmental stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nIMPACT plays a role in the mTOR signaling and integrated stress response pathways. Through these it influences protein synthesis and cellular stress management. IMPACT is related to proteins like GCN2 which allows cells to adapt to amino acid availability and eIF2α which is important for the translation initiation regulations in response to stress signals.\u003cbr\u003e\nAlterations in IMPACT expression have links to neurodegenerative diseases and mental health disorders. In Alzheimer's Disease for example its regulation of protein synthesis is considered important in disease progress interacting with other proteins like tau. Additionally through stress response modulation IMPACT is associated with mood disorders due to its role in synaptic plasticity and neuron survival under stress conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854010011817,"sku":"ab95175","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab95175","provider":"Iright","version":"1.0","type":"link"}