{"product_id":"abcam-ab97315","title":"Abcam, ab97315, Anti-RACGAP1\/MGCRACGAP antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal RACGAP1\/MGCRACGAP antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RACGAP1 aa 1-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human RACGAP1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9H0H5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein RACGAP1 also known as MGCRACGAP is an important component involved in the regulation of cytokinesis. This protein with an approximate mass of 63 kDa exhibits expression in various tissues including high levels in proliferative cell types such as those in tumors and testis. It interacts with Rho family GTPases playing a role in modulating the cytoskeleton during cell division. RACGAP1 localizes at the midbody of dividing cells marking its critical mechanical function in successful cytokinesis completion.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRACGAP1 plays an essential role in cell cycle regulation and mitotic progression. As a part of the centralspindlin complex it partners with kinesin-like protein CHICA to ensure the accurate completion of cytokinesis. This interaction fosters the stabilization and accumulation of microtubules at the spindle midzone which is fundamental for the cleavage furrow's ingression. RACGAP1's effective modulation of actin dynamics through its GAP activity serves a pivotal function in cytokinetic abscission.\u003cbr\u003e\nPathways\u003cbr\u003e\nRACGAP1 integrates into multiple signaling networks sharing responsibilities in regulating the dynamics of the mitotic spindle and the actomyosin contractile ring. Significant pathways include the Rho signaling pathway and the cell cycle checkpoint signaling. Within these pathways RACGAP1 works closely with proteins such as Aurora B kinase to orchestrate orderly cell division and chromosome segregation ensuring genomic stability.\u003cbr\u003e\nThe altered function of RACGAP1 links to several instances of tumorigenesis as well as certain developmental disorders. Overexpression and dysregulation have correlations with aggressive cancer phenotypes particularly in cases of prostate cancer. RACGAP1's oncogenic role becomes apparent through its interaction with proteins like p53 affecting tumor suppressor pathways. Addressing RACGAP1 anomalies through therapeutic intervention therefore presents a potential strategic target in treating related pathologies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848582418601,"sku":"ab97315","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab97315","provider":"Iright","version":"1.0","type":"link"}