{"product_id":"abcam-ab97646","title":"Abcam, ab97646, Anti-UGT1A6 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal UGT1A6 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUGT1A6 also known as UDP-glucuronosyltransferase 1A6 is an enzyme involved in the glucuronidation process which is critical for detoxifying and eliminating compounds from the body. This enzyme has a molecular mass of approximately 55 kDa. It is widely expressed in the liver as well as in the intestine and kidney where it catalyzes the transfer of glucuronic acid to various substrates. The enzyme achieves this by transforming small lipophilic molecules into more water-soluble forms for easier excretion.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe UGT1A6 enzyme functions in the phase II metabolism of various endogenous and exogenous substrates contributing to the body's defense mechanism. It is part of the larger UGT1A gene complex which includes several other UGT enzymes that share exon regions highlighting their evolutionary versatility. UGT1A6 primarily catalyzes the conjugation of planar phenols such as acetaminophen and a variety of other phenolic and aromatic amines. Through these activities the enzyme plays an integral role in maintaining metabolic balance.\u003cbr\u003e\nPathways\u003cbr\u003e\nUGT1A6 operates within detoxification and drug metabolism pathways including glucuronidation pathways for processing drugs and toxins. It interacts with cytochrome P450 enzymes which help in oxidative metabolism providing substrates for UGT1A6 to convert into more polar metabolites. The conjugative actions of UGT1A6 in these pathways facilitate efficient elimination of potentially harmful compounds and maintain metabolic homeostasis.\u003cbr\u003e\nMutations or altered expression of UGT1A6 can impact the body's drug-processing capabilities contributing to diseases such as Gilbert's syndrome and possible drug toxicity. In Gilbert's syndrome there is often a connection with UGT1A1 another UGT family enzyme leading to elevated levels of unconjugated bilirubin in the blood. UGT1A6's role in drug metabolism suggests that it may influence conditions related to drug sensitivity and resistance making it a significant factor in pharmacogenomics and personalized medicine approaches.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850157543593,"sku":"ab97646","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab97646","provider":"Iright","version":"1.0","type":"link"}