{"product_id":"abcam-ab99564","title":"Abcam, ab99564, Recombinant Human GAPR-1 protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human GAPR-1 protein is a Human Full Length protein, in the 1 to 154 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9H4G4,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPreviously labelled as GLIPR2.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGAPR-1 also known as Golgi-associated plant pathogenesis-related protein 1 is a protein with a molecular mass of approximately 17 kDa. It is expressed in several tissues with high levels in the brain and myeloid cells. Mechanically GAPR-1 plays a role in the regulation of membrane dynamics and protein-protein interactions at the Golgi apparatus. It contains a C-terminal cysteine-rich domain which is important for its localization and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGAPR-1 influences cellular processes related to the Golgi apparatus. It is not part of a large protein complex but acts independently to modulate lipid signaling and membrane trafficking. GAPR-1 impacts the intracellular transport and secretion of proteins contributing to cellular homeostasis and response to stress. It also affects the organization of Golgi membranes which is vital for maintaining Golgi structure and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nGAPR-1 operates in the phosphoinositide signaling pathway which is integral for various cellular processes like growth survival and trafficking. It has been linked to the modulation of phosphatidylinositol 4-phosphate levels influencing Golgi dynamics. Additionally GAPR-1 interacts with proteins such as protein kinase C which further connects it to cellular pathways involving signal transduction.\u003cbr\u003e\nGAPR-1 has connections to neurodegenerative diseases and immune system disorders. Its expression impacts lipid metabolism and membrane trafficking important factors in the development of Alzheimer's disease where abnormal protein aggregation occurs. GAPR-1 is also related to autoimmune conditions through its role in immune cell function and distribution. Its interaction with proteins involved in these diseases suggests its possible role as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844021375145,"sku":"ab99564","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab99564","provider":"Iright","version":"1.0","type":"link"}