{"product_id":"biolegend-102718","title":"Biolegend, 102718, PE\/Cyanine7 anti-mouse CD38 Antibody, 100μg","description":"\u003cp\u003eCD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse bone marrow pre-B cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed Wang YC, et al. 2023. J Exp Med. 220:. PubMed Ludwig J, et al. 2023. NPJ Vaccines. 8:52. PubMed Yazicioglu YF, et al. 2023. Nat Immunol. 24:991. PubMed Jiang W, et al. 2021. Sci Rep. 11:1864. PubMed D'Avola A, et al. 2022. J Clin Invest. 132: . PubMed Grégoire C, et al. 2022. Immunity. 55:1216. PubMed Hu Q, et al. 2022. Cell Rep. 40:111035. PubMed Shahid AM, et al. 2022. PLoS One. 17:e0278209. PubMed Voss LF, et al. 2023. Front Immunol. 13:1021370. PubMed Fontana MF, et al. 2023. Elife. 12: . PubMed Kodali S, et al. 2022. J Immunol. 208:1085. PubMed Zaiken M, et al. 2022. Blood. 139:2983. PubMed Degn SE et al. 2017. Cell. 170(5):913-926 . PubMed Shi B, et al. 2018. J Immunol. 200:586. PubMed Bauer KM, et al. 2022. JCI Insight. 7:. PubMed Chen J et al. 2018. Cell reports. 25(12):3393-3404 . PubMed Kim CC et al. 2019. Cell Rep. 27(5):1446-1460 . PubMed Jia X, et al. 2021. Clin Transl Immunology. 10:e1336. PubMed Juul-Madsen K, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed Muppidi J, et al. 2015. J Exp Med. 212: 2213 - 2222. PubMed Hilpert C, et al. 2016. J Immunol. 197: 2780 - 2786. PubMed Ly A, et al. 2020. Cell Reports. 29(8):2257-2269.e6.. PubMed Sato R, et al. 2020. Int Immunol. 499:32. PubMed Duan L, et al. 2021. Immunity. 54:2256. PubMed Mintz MA, et al. 2019. Immunity. 51:310. PubMed Ise W, et al. 2018. Immunity. 48:702. PubMed Barsoumian HB, et al. 2020. J Immunother Cancer. 8:00. PubMed Abbott RK, et al. 2018. Immunity. 48:133. PubMed Covarrubias AJ, et al. 2020. Nat Metab. 1265:2. PubMed Huang D, et al. 2020. Nat Commun. 4.520833333. PubMed Hilpert C, et al. 2019. J Immunol. 203:3068. PubMed Alexandre YO, et al. 2020. Cell Reports. 33(13):108567. PubMed Kajikawa A, et al. 2015. PLoS One. 10: e0141713. PubMed Riedel R, et al. 2020. Nat Commun. 11:2570. PubMed Firl DJ et al. 2018. eLife. 7 pii: e33051. PubMed Haniuda K, et al. 2020. Cell Rep. 33:108333. PubMed Teo TH, et al. 2018. Nat Commun. 9:3905. PubMed Andersen TK, et al. 2019. NPJ Vaccines. 4:9. PubMed Andersen TK, et al. 2021. Front Immunol. 12:747032. PubMed van der Poel CE, et al. 2019. Cell Rep. 29:2745. PubMed Kaji T, et al. 2012. J Exp Med. 209:2079. PubMed Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed Simoni L, et al. 2020. Cell Rep. 33:108330. PubMed Lederer K, et al. 2020. Immunity. 53(6):1281-1295.e5. PubMed Ryg-Cornejo V, et al. 2016. Cell Rep. 14:68-81. PubMed Smith LK, et al. 2021. Elife. 10:. PubMed Mesin L, et al. 2020. Cell. 180(1):92-106.e11.. PubMed Zhang B, et al. 2021. Nature. 599:471. PubMed Laczkó D, et al. 2020. Immunity. 53:724. PubMed Yu M, et al. 2012. Proc Natl Acad Sci U S A. 109:E879. PubMed Chen PM, et al. 2022. Sci Adv. 8:eabo4271. PubMed Trindade BC, et al. 2021. Immunity. 54:2273. PubMed Song W, et al. 2022. Immunity. 55:290. PubMed Li X, et al. 2021. Front Immunol. 12:779560. PubMed\u003cbr\u003e\nRRID: AB_2072892 (BioLegend Cat. No. 102717) AB_2275531 (BioLegend Cat. No. 102718)\u003cbr\u003e\nStructure: ADP-ribosyl hydrolase, 42 kD\u003cbr\u003e\nDistribution: B cells, NK cells, T cell subset, brain, muscle, kidney\u003cbr\u003e\nFunction: Regulation of cellular activation\/proliferation, adhesion, metabolism of cADPR and NAADP\u003cbr\u003e\nLigand\/Receptor: CD31, hyaluronic acid\u003cbr\u003e\nAntigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Shubinsky G, et al. 1997. Immunity 7:315. 3. Cesano A, et al. 1998. J. Immunol. 160:1106. 4. Cockayne DA, et al. 1998. Blood 92:1324.\u003cbr\u003e\nGene ID: 12494\u003cbr\u003e\nUniProt: View information about CD38 on UniProt.org\u003cbr\u003e\nClone: 90\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T10\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862498824361,"sku":"102718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-102718","provider":"Iright","version":"1.0","type":"link"}