{"product_id":"biolegend-104804","title":"Biolegend, 104804, PE anti-mouse CD33 Antibody, 100μg","description":"\u003cp\u003eCD33, also known as Siglec-3, Sigle, gp67, p67, and gp6, is a member of the sialic acid-binding immunoglobulin lectins (Siglec). CD33 extracellular portion contains two immunoglobulin domains (one IgV and one IgC2 domain). The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity. CD33 is primarily expressed on granulocytes in peripheral blood and spleen, as well as on myeloid precursors in the bone marrow.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: RBL1 Transfected with full length mCD33\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2927954 (BioLegend Cat. No. 104803) AB_2927954 (BioLegend Cat. No. 104804)\u003cbr\u003e\nStructure: Extracellular portion contains two immunoglobulin domains (IgV and IgC2 domain), intracellular portion contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs)\u003cbr\u003e\nDistribution: Granulocytes in peripheral blood and spleen, myeloid precursors in the bone marrow\u003cbr\u003e\nFunction: Inhibition of cellular activity\u003cbr\u003e\nLigand\/Receptor: Molecule with sialic acid residues\u003cbr\u003e\nCell Type: Dendritic cells, Granulocytes, Hematopoietic stem and progenitors, Mast cells, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: CD Molecules, Siglec Molecules\u003cbr\u003e\nAntigen References: Brinkman-Van der Linden, Els C M, et al. 2003. Mol Cell Biol. 23:4199-206.\u003cbr\u003e\nGene ID: 12489\u003cbr\u003e\nUniProt: View information about CD33 on UniProt.org\u003cbr\u003e\nClone: W18124D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67\u003cbr\u003e\nIsotype: Rat IgG2a, λ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866333728937,"sku":"104804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-104804","provider":"Iright","version":"1.0","type":"link"}