{"product_id":"biolegend-110402","title":"Biolegend, 110402, Purified anti-mouse CD202b (Tie-2, CD202) Antibody, 100μg","description":"\u003cp\u003eCD202b, also known as Tie-2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 also binds to Ang-4.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested IHC-F - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. For immunohistochemistry on frozen tissue sections, a concentration range of 5 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2922458 (BioLegend Cat. No. 110402)\u003cbr\u003e\nStructure: The receptor tyrosine kinase (RTK) family\u003cbr\u003e\nDistribution: Endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, T cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, CD Molecules\u003cbr\u003e\nAntigen References: Fathers KE, et al. 2005. Am. J. Pathol. 167:1753-62. Yano M, et al. 1997. Blood 89:4317-26. Kolatsi-Joannou M, et al. 2001. Dev. Dyn. 222:120-6.\u003cbr\u003e\nGene ID: 21687\u003cbr\u003e\nUniProt: View information about CD202b on UniProt.org\u003cbr\u003e\nClone: W19424P\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tie-2, TEK\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866417221801,"sku":"110402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-110402","provider":"Iright","version":"1.0","type":"link"}