{"product_id":"biolegend-114006","title":"Biolegend, 114006, APC anti-mouse CCRL2 Antibody, 100μg","description":"\u003cp\u003eCCRL2 (C-C chemokine receptor-like 2) is also known as Lipopolysaccharide-inducible C-C chemokine receptor (L-CCR\/Lccr). CCRL2 is a chemokine receptor-like, 7-transmembrane protein that can bind CCL19 or chemerin\/RARRES2. Mouse CCRL2 is expressed by several leukocytes, including dendritic cells, macrophages, neutrophils, and microglia and is rapidly upregulated following stimulation with proinflammatory stimuli, such as LPS and TNF-α. CCRL2 plays various roles in regulating chemokine activities, e.g., by binding and internalizing excess local levels of the CCL19\/MIP-3β chemokine. Alternatively, endothelial cell-expressed CCRL2 can bind \u0026amp; present the chemerin\/RARRES2 chemoattractant to lymphoid cells that express the functional signaling receptor, CMKLR1, and promote their adhesion.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CCRL2-Transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone S21013E completely blocks the reference clone BZ2E3.\u003cbr\u003e\nRRID: AB_3106135 (BioLegend Cat. No. 114005) AB_3106135 (BioLegend Cat. No. 114006)\u003cbr\u003e\nStructure: C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seventransmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family.\u003cbr\u003e\nDistribution: Expressed in many leukocytes, including dendritic cells, macrophages, neutrophils, mast cells, microglia \u0026amp; astrocytes\u003cbr\u003e\nFunction: CC-chemokine receptor-like 2 (CCRL2) binds leukocyte chemoattractant chemerin and can regulate local levels of the attractant, but does not itself support cell migration.\u003cbr\u003e\nInteraction: Macrophages, Dendritic Cells, Mast Cells\u003cbr\u003e\nLigand\/Receptor: CCL19 and chemerin\/RARRES2 bind to CCRL2\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Monnier J, et al. 2012. J Immunol. 2012; 189:956-67. Shimada T, et al. 1998. FEBS Lett. 1998; 425:490-4 Yoshimura T, et al. 2011. Exp Cell Res. 317:674-84. Zabel BA, et al. 2008. J Exp Med. 205:2207-20\u003cbr\u003e\nGene ID: 54199\u003cbr\u003e\nUniProt: View information about CCRL2 on UniProt.org\u003cbr\u003e\nClone: S21013E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: C-C chemokine receptor-like 2, L-CCR, Lipopolysaccharide-inducible C-C chemokine receptor (L-CCR), Cmkbr1l2, Ackr5\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866273534121,"sku":"114006","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-114006","provider":"Iright","version":"1.0","type":"link"}