{"product_id":"biolegend-115512","title":"Biolegend, 115512, APC anti-mouse CD19 Antibody, 100μg","description":"\u003cp\u003eCD19 is a 95 kD glycoprotein also known as B4. It is a member of the Ig superfamily, expressed on all pro-B to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19. CD19, in association with CD21 and CD81, forms a molecular complex integral to B cell activation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CD19-expressing K562 human erythroleukemia cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunofluorescence7.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Shoham T, et al. 2003. J. Immunol. 171:4062. (FC) Goodyear CS, et al. 2004. J. Immunol. 172:2870. (FC) Kamimura D, et al. 2006. J. Immunol. 177:306. (FC) Andoniou CE, et al. 2005. Nat. Immunol. 6:1011. (FC) Lawson BR, et al. 2007. J. Immunol. 178:5366. (FC) Phan TG, et al. 2007. Nat. Immunol. 8:992. (FC) Hayashida K, et al. 2008. J. Biol. Chem. 283:19895. (IF) PubMed Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed Bankoti J, et al. 2010. Toxicol. Sci. 115:422. (FC) PubMed Stadnisky MD, et al. 2011. Blood. 117:5133. (FC) PubMed Perlot T, et al. 2012. J. Immunol. 188:1201. (FC) PubMed Olive V, et al. 2013. Elife. 2:822. PubMed Miyai T, et al. 2014. PNAS. 111:11780. PubMed\u003cbr\u003e\nProduct Citations: Valladao A, et al. 2016. J Immunol. 197(12):4541-4551. PubMed Hou X, et al. 2020. Cell Reports. 28(1):172-189.e7.. PubMed Wei X, et al. 2022. Cell Rep. 40:111313. PubMed Cheng C, et al. 2022. Cell Mol Gastroenterol Hepatol. 15:261. PubMed Weier A, et al. 2022. Int J Mol Sci. 23:. PubMed Fu A, et al. 2022. Cell. 185:1356. PubMed Yang K, et al. 2022. Sci Immunol. 7:eabn2888. PubMed Urata S, et al. 2023. Microbiol Immunol. 67:105. PubMed Oh S, et al. 2023. Nat Biotechnol. :. PubMed Tan Y, et al. 2023. NPJ Regen Med. 8:7. PubMed Lentucci C, et al. 2017. J Biol Chem. 292:2754-2772. PubMed Schmidt M, et al. 2012. J Virol. 86:11654. PubMed Poh AR, et al. 2017. Cancer Cell. 31:563. PubMed Miyai T, et al. 2014. Proc Natl Acad Sci U S A. 111:1780. PubMed Wang J, et al. 2021. ACS Nano. 15:14360. PubMed Fu Y, et al. 2020. Mol Ther. 1214:28. PubMed Larsen SE, et al. 2021. Sci Rep. 11:9040. PubMed Brooks JF, et al. 2020. Cytotherapy. 22:436. PubMed Hayatsu N et al. 2017. Immunity. 47(2):268-283 . PubMed Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed Olive V, et al. 2009. Genes Dev. 2.929861111. PubMed Hoffman D, et al. 2021. Immunity. 54:2712. PubMed Lu Y, et al. 2020. Cell. 180(6):1081-1097. PubMed Sarapulov AV, et al. 2020. Front Immunol. 11:599. PubMed Delgado‐Benito V et al. 2018. Molecular cell. 72(4):636-649 . PubMed Best SA, et al. 2018. Cell Metab. 27:935. PubMed Mauduit O, et al. 2022. Front Immunol. 13:1011125. PubMed Horikoshi M, et al. 2012. PLoS One. 7:e51215. PubMed Ma L, et al. 2015. Blood. 126: 247 - 256. PubMed Wigton E, et al. 2016. J Leukoc Biol. 100: 143 - 153. PubMed Zhang B, et al. 2016. Mol Cell. 63: 976-89. PubMed Liang Z, et al. 2020. Pain. 161:2089. PubMed Riffelmacher T et al. 2017. Immunity. 47(3):466-480 . PubMed Fujita K, et al. 2019. Proc Natl Acad Sci U S A. 116:14714. PubMed Johnson MO et al. 2018. Cell. 175(7):1780-1795 . PubMed Socodato R, et al. 2020. Sci Signal. 13: . PubMed Wang X, et al. 2018. Mol Med Rep. 17:1660. PubMed Jasti S, et al. 2017. Biol Reprod. 96:134. PubMed Yue X, et al. 2019. Nat Commun. 10:2011. PubMed Wang W, et al. 2020. Immunity. 51(6):1102-1118.e7.. PubMed Xu H, et al. 2020. Immunity. 51(4):696-708.e9.. PubMed Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed Knocke S, et al. 2016. Cell Rep. 17:2234-2246. PubMed Lewis EL, et al. 2021. Front Immunol. 12:741518. PubMed Cook KD, et al. 2015. Immunity. 43:703-714. PubMed Lewandowski JP, et al. 2020. Genome Biol. 1.039583333. PubMed Fang H, et al. 2020. Nat Commun. 4.661805556. PubMed Ko S, et al. 2009. J Virol. 83:748. PubMed Nahrendorf W, et al. 2021. eLife. 10:00. PubMed Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed Luck H, et al. 2019. Nat Commun. 10:3650. PubMed Metidji A et al. 2018. Immunity. 49(2):353-362 . PubMed Olson B, et al. 2021. Brain Behav Immun. 97:102. PubMed Olive V, et al. 2013. Elife. 2:822. PubMed Ligon MM, et al. 2020. Mucosal Immunol. 1.172222222. PubMed Jing Y, et al. 2021. Front Immunol. 12:651860. PubMed Baglaenko Y, et al. 2016. PLoS One. 11: 0150515. PubMed Bazett M, et al. 2012. J Immunol. 188:2297. PubMed Amezcua Vesely MC, et al. 2020. Cell. 178(5):1176-1188.e15.. PubMed Wang X, et al. 2021. Cell. 184:5357. PubMed Alenazy MF, et al. 2022. PLoS One. 17:e0271689. PubMed Kim MY, et al. 2022. Nat Commun. 13:3296. PubMed Liu J, et al. 2015. Sci Rep. 5: 13558. PubMed Di Pilato M, et al. 2021. Cell. 184(17):4512-4530.e22. PubMed Cao A, et al. 2018. Nat Commun. 9:3288. PubMed Kimura S, et al. 2020. Am J Transplant. 20:977. PubMed Li S, et al. 2016. Sci Rep. 6:20425. PubMed Pelly V, et al. 2016. Mucosal Immunol. 10.1038\/mi.2016.4. PubMed Aalipour A, et al. 2020. Mol Ther Oncolytics. 17:232. PubMed Kunishita Y, et al. 2020. Front Immunol. 11:98. PubMed Rusconi M, et al. 2017. Sci Rep. 5.745138889. PubMed Che N, et al. 2021. Front Immunol. 12:626310. PubMed Rappe JCF, et al. 2021. J Exp Med. 218:. PubMed Chow AK, et al. 2021. Cellular and Molecular Gastroenterology and Hepatology. :. PubMed Omenetti S, et al. 2019. Immunity. 51:77. PubMed Hester AK, et al. 2022. Cell Rep. 38:110363. PubMed Amend A, et al. 2021. Int J Mol Sci. 22:. PubMed\u003cbr\u003e\nRRID: AB_313646 (BioLegend Cat. No. 115511) AB_313647 (BioLegend Cat. No. 115512)\u003cbr\u003e\nStructure: Ig superfamily, associates with CD21 and CD81, 95 kD\u003cbr\u003e\nDistribution: Pro-B cells to mature B cells (during development), follicular dendritic cells\u003cbr\u003e\nFunction: Modulates B cell activation and differentiation\u003cbr\u003e\nLigand\/Receptor: CD21, CD81, Leu-13\u003cbr\u003e\nCell Type: B cells, Dendritic cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Fearon DT. 1993. Curr. Opin. Immunol. 5:341. 2. Krop I, et al. 1996. Eur. J. Immunol. 26:238. 3. Krop I, et al. 1996. J. Immunol. 157:48. 4. Tedder TF, et al. 1994. Immunol. Today 15:437.\u003cbr\u003e\nGene ID: 12478\u003cbr\u003e\nUniProt: View information about CD19 on UniProt.org\u003cbr\u003e\nClone: 6D5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: B4\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862475755689,"sku":"115512","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-115512","provider":"Iright","version":"1.0","type":"link"}