{"product_id":"biolegend-117202","title":"Biolegend, 117202, Purified anti-mouse CD73 Antibody, 100μg","description":"\u003cp\u003eCD73 (ecto-5'-nucleotidase) is a 69 kD GPI-anchored surface protein. In mice, expression of CD73 in bone marrow is restricted to CD11b+ myeloid cells. In spleen, it is largely expressed on T cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: BALB\/c mouse splenocytes and CHO cells transfected with the mouse CD73 gene, Nt5\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: The TY\/23 antibody has been reported to inhibit the enzymatic activity of CD73.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): 1. Zhang B. 2010. Cancer Res. 70:6407-11. 2. Stagg J, et al. 2010. Proc Natl Acad Sci U S A. 107:1547-52. 3. Forte G, et al. 2012. J Immunol. 189:2226-33.\u003cbr\u003e\nRRID: AB_2936539 (BioLegend Cat. No. 117202)\u003cbr\u003e\nStructure: 69 kD GPI-anchored surface protein\u003cbr\u003e\nDistribution: Positive on most CD11b+ myeloid cells in bone marrow, but not on CD11b+ peripheral cells; a large proportion of CD4+ and CD8+ splenic T cells express CD73\u003cbr\u003e\nFunction: A nucleotidase catalyzing the dephosphorylation of extracellular nucleoside 5' monophosphates\u003cbr\u003e\nLigand\/Receptor: Nucleoside 5' monophosphate\u003cbr\u003e\nCell Type: B cells, Mesenchymal Stem Cells, Tregs\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Yamashita Y, et al. 1998. Eur J Immunol. 28:2981-90. Resta R, et al. 1998. Immunol Rev. 161:95-109.\u003cbr\u003e\nGene ID: 23959\u003cbr\u003e\nUniProt: View information about CD73 on UniProt.org\u003cbr\u003e\nClone: TY\/23\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: 5'-nucleotidase, Nt5e, 5'-NT, Ecto-5'-nucleotidase\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864062513321,"sku":"117202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-117202","provider":"Iright","version":"1.0","type":"link"}