{"product_id":"biolegend-119103","title":"Biolegend, 119103, APC anti-mouse CD255 (TWEAK) Antibody, 25μg","description":"\u003cp\u003eCD255, also known as TWEAK (TNF-related weak inducer of apoptosis), is a 27 kD protein and a tumor necrosis factor superfamily member 12 (TNFSF12). TWEAK is a type II transmembrane protein expressed on a variety of cell types. A soluble form of TWEAK is produced by proteolytic processing. TWEAK binds to the TWEAK receptor, FN14, to induce apoptosis, NF-κB translocation, and promote angiogenesis and endothelial cell proliferation. It has also been implicated in the induction of inflammatory cytokines.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant mouse CD255 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3106006 (BioLegend Cat. No. 119103) AB_3106006 (BioLegend Cat. No. 119104)\u003cbr\u003e\nStructure: TNF superfamily member; type II membrane protein and secreted; homotrimer, 27 kD\u003cbr\u003e\nDistribution: Widely expressed; induced on activated CD4+ cells\u003cbr\u003e\nFunction: Weak inducer of apoptosis in some cell types, activates NF-κB, promotes angiogenesis and endothelial cell proliferation, induces inflammatory cytokine production\u003cbr\u003e\nLigand\/Receptor: TWEAKR\/FN14\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Angiogenesis, Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Chicheportiche Y, et al. 1997. J. Biol. Chem. 272:32401-10. Schneider P, et al. 1999. Eur. J. Immunol. 29:1785-92.\u003cbr\u003e\nGene ID: 21944\u003cbr\u003e\nUniProt: View information about CD255 on UniProt.org\u003cbr\u003e\nClone: A19079J\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TNFSF12, TNF-related weak inducer of apoptosis\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866066833577,"sku":"119103","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-119103","provider":"Iright","version":"1.0","type":"link"}