{"product_id":"biolegend-121601","title":"Biolegend, 121601, Purified anti-mouse CD107a (LAMP-1) Antibody, 50μg","description":"\u003cp\u003eCD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: This monoclonal antibody was raised against NIH\/3T3 mouse embryonic fibroblast tissue culture cell membranes. It has been mapped to the N-terminus of LAMP-1.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested WB - Verified ICC, IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Morisaki Y, et al. 2016. Sci Rep. 6:27354. PubMed Zhou D, et al. 2018. Oncotarget. 9:5184. PubMed Miyatake Y, et al. 2018. J Immunol. 201:3051. PubMed Kim S, et al. 2023. Sci Rep. 13:5665. PubMed Zeng J, et al. 2023. Nat Commun. 14:2573. PubMed Roblek M, et al. 2022. Front Oncol. 12:777634. PubMed Tersteegen A, et al. 2021. Infect Immun. 89:. PubMed Yan J, et al. 2020. Cancer Discov. 10:124. PubMed Blériot C, et al. 2020. Methods Mol Biol. 2164:87. PubMed Wong AYW, et al. 2018. Front Immunol. 9:210. PubMed Warburg G, et al. 2014. J Cell Biol. 204:423. PubMed Steptoe R, et al. 2007. J Immunol . 178:2094. PubMed Hasegawa J, et al. 2016. EMBO J. 35: 1853 - 1867. PubMed Reichenbach N, et al. 2018. J Exp Med. 215:1649. PubMed Tan L, et al. 2017. Int J Nanomedicine. 12:3095. PubMed Reichenbach N, et al. 2019. EMBO Mol Med. 11:. PubMed Yan J, et al. 2020. Cancer Immunol Res. 8:356. PubMed Stacey MA, et al. 2017. J Clin Invest. 127:1463. PubMed Morioka S, et al. 2018. J Cell Sci. 131. PubMed Takemasu S, et al. 2019. J Biochem. 166:175. PubMed Hsiao CC, et al. 2021. Cells. 10:. PubMed Bussi C, et al. 2018. J Cell Sci. 131. PubMed Blriot C, et al. 2021. Immunity. :. PubMed Daley D, et al. 2017. Nat Med. 23:556. PubMed Tan CL, et al. 2018. Immunohorizons. 0.248611111. PubMed Stykel MG, et al. 2021. Cell Reports. 35(6):109099. PubMed D'Agostino M, et al. 2011. J Cell Sci. 124:3545. PubMed Wagner AK, et al. 2017. Nat Commun. 8:15627. PubMed Stelekati E, et al. 2018. Cell Rep. 2.445833333. PubMed Maier B, et al. 2020. Nature. 580:257. PubMed\u003cbr\u003e\nRRID: AB_572020 (BioLegend Cat. No. 121601) AB_572021 (BioLegend Cat. No. 121602)\u003cbr\u003e\nStructure: LAMP-1 is a 406 amino acid protein with a molecular mass of 44 kD.\u003cbr\u003e\nGene ID: 16783\u003cbr\u003e\nUniProt: View information about CD107a on UniProt.org\u003cbr\u003e\nClone: 1D4B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lysosome-associated membrane glycoprotein 1, lysosomal membrane glycoprotein 1, CD107 antigen-like family member A, lysosome-associated membrane protein 1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860854689961,"sku":"121601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-121601","provider":"Iright","version":"1.0","type":"link"}