{"product_id":"biolegend-121605","title":"Biolegend, 121605, FITC anti-mouse CD107a (LAMP-1) Antibody, 50μg","description":"\u003cp\u003eCD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: This monoclonal antibody was raised against NIH\/3T3 mouse embryonic fibroblast tissue culture cell membranes. It has been mapped to the N-terminus of LAMP-1.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nProduct Citations: Villarreal D, et al. 2015. Vaccine. 33: 4313-4320. PubMed Miyatake Y, et al. 2018. J Immunol. 201:3051. PubMed Tan X, et al. 2023. Adv Sci (Weinh). 10:e2206768. PubMed Capellmann S, et al. 2023. Front Immunol. 14:1154416. PubMed Gary EN, et al. 2022. Cell Rep Med. 3:100693. PubMed Wei M, et al. 2022. Front Immunol. 13:1017574. PubMed Rosenheinrich M, et al. 2015. PLoS One. 10: 0136290. PubMed Page N, et al. 2018. Immunity. 48:937. PubMed Koh CH, et al. 2020. Cancer Immunol Res. 8:698. PubMed Konrath KM, et al. 2022. Cell Rep. 38:110318. PubMed Mitchell JE, et al. 2021. Cell Reports. 35(2):108966. PubMed Bourn JR, et al. 2021. Cancer Lett. 503:75. PubMed Nagarajan D, et al. 2021. Immunol Cell Biol. 99:972. PubMed Panciera T, et al. 2016. Cell Stem Cell. 19:725-737. PubMed Gary EN, et al. 2021. iScience. 24(7):102699. PubMed Goggi JL, et al. 2020. Mol Imaging Biol. 22:1392. PubMed Wang F, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:257. PubMed Zhou D, et al. 2022. Nat Commun. 13:5174. PubMed Wagle MV, et al. 2021. Nat Commun. 12:2782. PubMed Chen Z et al. 2019. Immunity. 51(5):840-855 . PubMed Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed Volberding PJ, et al. 2021. Cell Reports. 35(8):109160. PubMed Yan Y, et al. 2018. JCI Insight. 3. PubMed Zuo S, et al. 2021. J Immunother Cancer. 9:. PubMed Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed Zhang Y, et al. 2018. Nat Commun. 9:6. PubMed Klein JC, et al. 2017. Nat Commun. 8:14600. PubMed Nembrini C, et al. 2011. Proc Natl Acad Sci U S A. 108:E989. PubMed He Y, et al. 2017. J Autoimmun. 10.1016\/j.jaut.2017.04.001. PubMed Oliveira AC et al. 2017. eLife. 6 pii: e30883. PubMed Chen Z, et al. 2021. Cell. 184(5):1262-1280.e22. PubMed Bransi A, et al. 2015. Cancer Immunol Res. 3: 1279 - 1288. PubMed Reguzova A, et al. 2020. Vaccines (Basel). 8:. PubMed Tanegashima K et al. 2017. EBioMedicine. 24:247-256 . PubMed Wolf Y, et al. 2019. Cell. 179:219. PubMed\u003cbr\u003e\nRRID: AB_572006 (BioLegend Cat. No. 121605) AB_572007 (BioLegend Cat. No. 121606)\u003cbr\u003e\nStructure: LAMP-1 is a 406 amino acid protein with a molecular mass of 44 kD.\u003cbr\u003e\nGene ID: 16783\u003cbr\u003e\nUniProt: View information about CD107a on UniProt.org\u003cbr\u003e\nClone: 1D4B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lysosome-associated membrane glycoprotein 1, lysosomal membrane glycoprotein 1, CD107 antigen-like family member A, lysosome-associated membrane protein 1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860853641385,"sku":"121605","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-121605","provider":"Iright","version":"1.0","type":"link"}