{"product_id":"biolegend-122305","title":"Biolegend, 122305, FITC anti-mouse DLK1 Antibody, 25μg","description":"\u003cp\u003eThe Delta-Notch pathway controls developmental processes including cell fate determination, terminal differentiation, and proliferation. In mammals, four Notch receptors (NOTCH1–4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. Delta-like 1 homolog (DLK1) is a noncanonical Notch ligand, and acts as an inhibitor of Notch signaling. The inhibitory effect of DLK1 and DLK2 on Notch signaling may be mediated by competition with canonical ligands for the receptor binding site. Widely expressed during embryonic development, expression becomes restricted in the adult to neuroendocrine tissues like the pituitary gland, adrenal glands, pancreas, monoaminergic neurons in the central nervous system, testes, prostate, and ovaries.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: mDLK1-RBL1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nRRID: AB_3097345 (BioLegend Cat. No. 122305) AB_3097345 (BioLegend Cat. No. 122306)\u003cbr\u003e\nStructure: Single-pass type I membrane protein\u003cbr\u003e\nDistribution: Cytoplasm, plasma membrane\u003cbr\u003e\nFunction: Neuroendocrine differentiation, inhibits adipocyte differentiation\u003cbr\u003e\nInteraction: Notch receptors\u003cbr\u003e\nLigand\/Receptor: Notch receptors\u003cbr\u003e\nCell Type: Fibroblasts, Neurons\u003cbr\u003e\nBiology Area: Neuroscience, Signal Transduction\u003cbr\u003e\nAntigen References: Smas C.M, et al. 1993. Cell. 73:725-34. Laborda J, et al. 1993. J Biol Chem. 268:3817-20. Montalban-Loro R, et al. 2021. Proc Natl Acad Sci USA. 118 (11). Zhang L, et al. 2021. Stem Cells. 39:306-17. Ichinose M, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 320:G506-20.\u003cbr\u003e\nGene ID: 13386\u003cbr\u003e\nUniProt: View information about DLK1 on UniProt.org\u003cbr\u003e\nClone: W21075D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Pref, protein delta homolog 1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866429149353,"sku":"122305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-122305","provider":"Iright","version":"1.0","type":"link"}