{"product_id":"biolegend-127409","title":"Biolegend, 127409, APC anti-mouse Podoplanin Antibody, 25μg","description":"\u003cp\u003eThe mucin-type glycoprotein podoplanin is thought to be involved in the development of the lymphatic vascular system. Podoplanin is named after its expression in the kidney glomerular epithelial cells (podocytes). It has a potential role in tumor progression.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Syrian Hamster\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: immunohistochemistry6, and spatial biology (IBEX)8,9.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Farr A, et al. 1992. J. Histochem. Cytochem. 40:651. Farr AG, et al. 1992. J. Exp. Med. 176:1477. Bekiaris V, et al. 2008. J. Immunol. 180:6768. Algars A, et al. 2011. Blood 117:4387. PubMed Reis VO, et al. 2012. Immunobiology. 217:831. PubMed Kaji C, et al. 2012. Acta. Histochem. Cytochem. 45:227. (IHC) Kretschmer S, et al. 2013. PLoS One. 8:e52201. PubMed. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed\u003cbr\u003e\nProduct Citations: Cheong LY, et al. 2023. Nat Commun. 14:1213. PubMed Hutton C, et al. 2021. Cancer Cell. 39:1227. PubMed Buechler MB, et al. 2021. Nature. 593:575. PubMed Ozga AJ, et al. 2022. Immunity. 55:82. PubMed Garnier L, et al. 2022. Sci Adv. 8:eabl5162. PubMed Jiang W, et al. 2022. Redox Biol. 56:102432. PubMed Krishnamurty AT, et al. 2022. Nature. 611:148. PubMed Tomiaki C, et al. 2022. Front Immunol. 13:1014462. PubMed Sastourné-Arrey Q, et al. 2023. Nat Commun. 14:80. PubMed Urban SK, et al. 2020. Liver Int. 40:3103. PubMed Weeden C, et al. 2017. PLoS Biol. 10.1371\/journal.pbio.2000731. PubMed McCarthy N, et al. 2020. Cell Stem Cell. 391:26. PubMed Rodda LB et al. 2018. Immunity. 48(5):1014-1028 . PubMed Seidenberg J, et al. 2021. Int J Mol Sci. :22. PubMed Brinkman C, et al. 2013. J Immunol. 191:2412. PubMed Schwab M, et al. 2021. Exp Dermatol. 30:1619. PubMed Davidson S, et al. 2020. Cell Reports. 31(7):107628. PubMed Jackson-Jones LH, et al. 2020. Immunity. 52:700. PubMed Duan L, et al. 2021. Immunity. 54:2256. PubMed Donati Y, et al. 2020. Am J Physiol Lung Cell Mol Physiol. L619:318. PubMed Walsh SM, et al. 2021. eLife. 10:00. PubMed Grauel AL, et al. 2020. Nat Commun. 4.84375. PubMed Clement CC, et al. 2021. Nat Commun. 12:4447. PubMed Matthew B Buechler et al. 2019. Immunity. 51(1):119-130 . PubMed Denton A, et al. 2014. Proc Natl Acad Sci U S A. 111:12139. PubMed Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed Eisemann T, et al. 2019. Front Oncol. 9:187. PubMed Shaikh H, et al. 2021. Front Immunol. 12:689896. PubMed Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed Blaskovic S, et al. 2020. Am J Physiol Lung Cell Mol Physiol. L606:318. PubMed Coulombe P et al. 2019. Cell reports. 27(6):1769-1780 . PubMed Hara T, et al. 2021. Cancer Cell. 39(6):779-792.e11. PubMed Hirota K et al. 2018. Immunity. 48(6):1220-1232 . PubMed Kurashima Y, et al. 2021. Nat Commun. 12:1067. PubMed Tadayon S, et al. 2021. Front Immunol. 12:602122. PubMed Costa B, et al. 2019. Blood Adv. 3:1092. PubMed\u003cbr\u003e\nRRID: AB_10612940 (BioLegend Cat. No. 127409) AB_10613649 (BioLegend Cat. No. 127410)\u003cbr\u003e\nStructure: 43 Kd glycosylated type-1 transmembrane protein. Mucin-type protein.\u003cbr\u003e\nDistribution: Expressed on epithelial and mesothelial cells.\u003cbr\u003e\nCell Type: Epithelial cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nAntigen References: 1. Farr A, et al. 1992. J. Histochem. Cytochem. 40:651. 2. Schacht V, et al. 2005. Am. J. Pathol. 166:913.\u003cbr\u003e\nGene ID: 14726\u003cbr\u003e\nUniProt: View information about Podoplanin on UniProt.org\u003cbr\u003e\nClone: 8.1.1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T1a, gp38, stromal cell marker\u003cbr\u003e\nIsotype: Syrian Hamster IgG\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862490894505,"sku":"127409","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-127409","provider":"Iright","version":"1.0","type":"link"}