{"product_id":"biolegend-129006","title":"Biolegend, 129006, PE anti-mouse Tim-2 Antibody, 100μg","description":"\u003cp\u003eTim-2 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-2. It is expressed on activated T cells and preferentially on differentiated Th 2 cells. Sema4A is the ligand of Tim-2. A blockade of Tim-2\/Tim-2 ligand interaction results in T cell hyperproliferation and Th 2 cytokine production. Tim-2 plays a critical role in the development of atopic disease and other Th 2 -biased immune responses.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance in each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_1227792 (BioLegend Cat. No. 129006)\u003cbr\u003e\nStructure: Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD\u003cbr\u003e\nDistribution: Developmentally regulated; highly expressed in embryonic development at the 8-cell stage and blastocyst. Expressed on activated T lymphocytes.\u003cbr\u003e\nLigand\/Receptor: Sema4A, H-ferritin\u003cbr\u003e\nCell Type: T cells, Embryonic Stem Cells\u003cbr\u003e\nBiology Area: Immunology, Stem Cells\u003cbr\u003e\nAntigen References: 1. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.2. Kumanogoh A, et al. 2002. Nature 419:629.3. Chakravarti S, et al. 2005. J. Exp. Med. 202:437\u003cbr\u003e\nGene ID: 171284\u003cbr\u003e\nUniProt: View information about Tim-2 on UniProt.org\u003cbr\u003e\nClone: F37-2C4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: T cell immunoglobulin and mucin domain containing protein-2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863081308329,"sku":"129006","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-129006","provider":"Iright","version":"1.0","type":"link"}