{"product_id":"biolegend-132308","title":"Biolegend, 132308, APC anti-mouse CD132 (common γ chain) Antibody, 100μg","description":"\u003cp\u003eCD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common γ chain (γc) or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK\/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Kondo M, et al. 1993. Science 262:1874 (Block)Kondo M, et al. 1994. Science 263:1453 Kimura Y, et al. 1995. Int Immunol. 7:115 (Block)Veerman KM, et al. 2012. J. Immunol. 188:1638. PubMed. Hennion-Tscheltzoff O, et al. 2013. Blood. 121:4684. PubMed\u003cbr\u003e\nProduct Citations: Zhou D, et al. 2022. Nat Commun. 13:5174. PubMed Glassman CR, et al. 2021. eLife. 10:00. PubMed Yue X, et al. 2021. EMBO Rep. 22:e52716. PubMed Fan MY et al. 2018. Cell reports. 25(5):1204-1213 . PubMed Zheng Y, et al. 2022. J Immunol. 208:501. PubMed\u003cbr\u003e\nRRID: AB_10643575 (BioLegend Cat. No. 132307) AB_10643576 (BioLegend Cat. No. 132308)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein, Ig superfamily 64-70 kD\u003cbr\u003e\nDistribution: T cells, B cells, NK, monocytes, granulocytes\u003cbr\u003e\nFunction: Signaling\u003cbr\u003e\nLigand\/Receptor: Component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21\u003cbr\u003e\nCell Type: T cells, B cells, NK cells, Monocytes, Granulocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Itano M, et al. 1996. Tohoku J. Exp. Med. 178:3892. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley \u0026amp; Sons Inc, Publication 3. Nakarai T, et al. 1994. J. Exp. Med. 180:241 4. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724 5. Habib T, et al. 2002. Biochemistry. 41:8725 6. Matthews DJ, et al. 1995. Blood 85:38\u003cbr\u003e\nGene ID: 16186\u003cbr\u003e\nUniProt: View information about CD132 on UniProt.org\u003cbr\u003e\nClone: TUGm2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Common γ chain, γc, IL-2 receptor γ subunit\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864055369897,"sku":"132308","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-132308","provider":"Iright","version":"1.0","type":"link"}