{"product_id":"biolegend-132703","title":"Biolegend, 132703, PE anti-mouse MAIR-V Antibody, 25μg","description":"\u003cp\u003eThe myeloid-associated immunoglobulin-like receptor family (CD300) consists of nine activating or inhibitory cell surface receptors preferentially expressed on myloid cells and are encoded by the genes in a small cluster on mouse chromosome 11. MAIR-V is one of the family members. MAIR-V regulates the activation of myeloid cells. It has been reported that cross-linking MAIR-V with anti-MAIR-V monoclonal antibody induced cell death in peritoneal macrophages as well as transfectants. Data suggested that MAIR-V is one of the inhibitory receptors in the family. The functional of characteristics of this receptor are still not clear. Monoclonal antibody TX70 recognized both MAIR-Va and MAIR-Vb.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: MAIR-V transfectant (BW5147)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.015 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Graziano VR, et al. 2020. PLoS Pathog. 16:e1008242. PubMed\u003cbr\u003e\nRRID: AB_2074116 (BioLegend Cat. No. 132704)\u003cbr\u003e\nStructure: MAIR-V belongs to the myeloid-associated immunoglobulin-like receptor family. It has two isoforms, MAIR-Va and MAIR-Vb. MAIR-V contains a consensus immunoreceptor tyrosine-based switching motif (ITSM) as well as two ITIMs in the cytoplasmic tail.\u003cbr\u003e\nDistribution: It was reported that CD300LF is expressed on myeloid cells, including macrophages, neutrohils, DCs, and bone marrow derived mast cells. The expression profile of MAIR-V is still incompletely understood.\u003cbr\u003e\nCell Type: Macrophages, Neutrophils, Dendritic cells, Mast cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Can Ismail, et al. 2008. Hybridoma. 27 (1):59-612. Can Ismail, et al. 2008. J. Immunol. Sep; 180:207-2133. Totsumoto K, et al. 2003. J. Exp. Med. 198:223-233\u003cbr\u003e\nGene ID: 246746\u003cbr\u003e\nUniProt: View information about MAIR-V on UniProt.org\u003cbr\u003e\nClone: TX70\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD300LF, CD300f, CMRF35-like molecule 1, Myeloid-associated immunoglobulin-like receptor 5\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864061071529,"sku":"132703","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-132703","provider":"Iright","version":"1.0","type":"link"}