{"product_id":"biolegend-134104","title":"Biolegend, 134104, PE anti-mouse CD268 (BAFF-R) Antibody, 100μg","description":"\u003cp\u003eBAFF (B cell-activating factor belonging to the TNF family) receptor (BAFF-R) is one of the three receptors that bind to BAFF. It is a type III transmembrane TNF receptor family member. BAFF-R is expressed at high levels in resting B cells and at lower levels in activated B cells, a small subset of activated\/memory CD4 + T cells. It is a major mediator of BAFF dependent co-stimulatory response in peripheral B and T cells. It was reported that the mice expressing defective BAFF-R have disrupted B cell maturation. BAFF receptor appears to be particularly important for the regulation of normal B cell survival and maturation, as well as in the pathophysiology of aggressive B-cell malignancies and autoimmune diseases.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse BAFF receptor transfected rat RBL cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ng LG, et al. 2006. Eur. J. Immunol. 36:1837. Ng LG, et al. 2004. J Immunol. 173:807. Batten M, et al. 2000. J. Exp. Med. 192:1453. Fu L, et al. 2009. Blood 113:4627.\u003cbr\u003e\nProduct Citations: Chappaz S, et al. 2021. Cell Reports. 36(3):109430. PubMed Shikatani EA et al. 2019. Cell Rep. 27(8):2304-2312 . PubMed Souza SP, et al. 2021. PLoS Pathog. 17:e1010081. PubMed Hamilton J,et al. 2017. J Immunol. 10.4049\/jimmunol.1700888. PubMed Silva N, et al. 2016. J Immunol. 196: 2591 - 2601. PubMed Hodgson R, et al. 2022. Commun Biol. 5:1216. PubMed\u003cbr\u003e\nRRID: AB_1626160 (BioLegend Cat. No. 134103) AB_2203552 (BioLegend Cat. No. 134104)\u003cbr\u003e\nStructure: A type III transmembrane TNF receptor family member\u003cbr\u003e\nDistribution: Expressed on most B cells, a small subset of CD4+ T cells.\u003cbr\u003e\nFunction: Play an importance role in B cell development, maturation, and survival.\u003cbr\u003e\nLigand\/Receptor: BAFF (BLyS)\u003cbr\u003e\nCell Type: B cells, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: 1. Thompson JS, et al. 2001. Science 293:2108. 2. Schiemann B, et al. 2001. Science 293:2111. 3. Batten M, et al. 2000. J. Exp. Med. 192:1453. 4. Fu L, et al. 2009. Blood 113:4627.\u003cbr\u003e\nGene ID: 72049\u003cbr\u003e\nUniProt: View information about CD268 on UniProt.org\u003cbr\u003e\nClone: 7H22-E16\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BR3, BAFFR, BAFF receptor, TNFRSF13C, B cell-activating factor receptor, BLys receptor 3\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862490271913,"sku":"134104","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-134104","provider":"Iright","version":"1.0","type":"link"}