{"product_id":"biolegend-134202","title":"Biolegend, 134202, Purified anti-mouse CD178 (FasL) Antibody, 100μg","description":"\u003cp\u003eCD178 is a 40 kD member of the TNF superfamily also known as Fas ligand or FasL. Cell surface CD178 is expressed on activated T cells and in testis and eye. CD178 is upregulated in activated T cells upon TCR re-engagement and has been shown to induce T cell death. CD178 expression in the eye and testis has been shown to participate in immune privilege at these sites. CD178 can be cleaved from the surface by metalloproteases, and \"soluble\" CD178 may block the activities of membrane-bound CD178. CD178 binds to CD95 (Fas) to induce apoptotic cell death implicated in the maintenance of peripheral tolerance. CD178\/CD95 interactions have also been implicated in the proliferation of CD8+ cells and neutrophil extravasation, chemotaxis, and survival.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant mouse FasL\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone A19116F does not affect the binding of clone MFL3 on target cells.\u003cbr\u003e\nRRID: AB_2936669 (BioLegend Cat. No. 134202)\u003cbr\u003e\nStructure: TNF superfamily, 40 kD\u003cbr\u003e\nDistribution: Activated T cells, spleen, testis, eye\u003cbr\u003e\nFunction: Induces apoptosis\u003cbr\u003e\nLigand\/Receptor: Fas (CD95)\u003cbr\u003e\nCell Type: T cells, Tregs\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cancer Biomarkers, Cell Biology, Immunology, Neuroscience\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. Nagata S. 1999. Annu Rev Genet. 33:29-55. Takahashi T, et al. 1994. Cell. 76:969-76. Hill LL, et al. 1999. Science. 285:898-900.\u003cbr\u003e\nGene ID: 14103\u003cbr\u003e\nUniProt: View information about CD178 on UniProt.org\u003cbr\u003e\nClone: A19116F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866067095721,"sku":"134202","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-134202","provider":"Iright","version":"1.0","type":"link"}