{"product_id":"biolegend-137910","title":"Biolegend, 137910, Alexa Fluor® 647 anti-mouse Galectin-9 Antibody, 100μg","description":"\u003cp\u003eGalectin-9 is a mammalian lectin with a molecular weight of 40 kD that has two conserved carbohydrate recognition domains (CRDs) and forms homodimers. It recognizes N-acetyllactosamine (Galbeta1-4GlcNAc) and T-antigen (Galbeta1-3GalNAc); Tim-3 has been reported as its ligand. Galectin-9 is expressed by lymphocytes, dendritic cells, granulocytes, eosinophils, astrocytes, endothelial cells, fibroblasts and thymus epithelial cells. It may be retained intracellularly or be transported to the cell surface where it is cleaved, thereby generating a soluble form. Galectin-9 is involved in events such as cell aggregation, cell adhesion, chemotaxis and apoptosis. Importantly for the regulation of the immune response, Galectin-9 induces regulatory T cells and suppresses Th1 and Th17 responses.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Full length recombinant mouse Galectin-9 (M-type)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: IHC-F - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration range of 5 - 10 µg\/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone 108A2 recognizes the linker peptide of mouse Galectin-9; it does not cross-react with stable Galectin-9 (which is biologically active, genetically engineered, linker-less Galectin-9)3. Additional reported applications (for the relevant formats) include: sandwich ELISA as capture antibody1 and immunohistochemical staining of paraffin2 embedded tissue sections.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Tsuboi Y, et al. 2007. Clin. Immunol. 124:221. (ELISA) Personal communication. (IHC-Paraffin) Oomizu S, et al. 2012. PLoS One. 7:e48574. PubMed Madireddi S, et al. 2014. J Exp Med. 211:1433. PubMed\u003cbr\u003e\nRRID: AB_2810406 (BioLegend Cat. No. 137909) AB_2810407 (BioLegend Cat. No. 137910)\u003cbr\u003e\nStructure: Homodimer, each chain is a 343 aa protein of 40 kD that has two conserved carbohydrate recognition domains (CRDs)\u003cbr\u003e\nDistribution: Lymphocytes, dendritic cells, neutrophils, eosinophils, astrocytes, endothelial cells, fibroblasts, thymus stromal\/epithelial cells\u003cbr\u003e\nFunction: Cell aggregation, cell adhesion, chemotaxis, apoptosis, suppression of Th1 and Th17 responses, induction of regulatory T cells\u003cbr\u003e\nLigand\/Receptor: Tim-3\u003cbr\u003e\nCell Type: Astrocytes, Dendritic cells, Endothelial cells, Eosinophils, Epithelial cells, Fibroblasts, Lymphocytes, Neutrophils, Tregs\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Adhesion, Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: 1. Klibi J, et al. 2009. Blood 113:1957. 2. Seki M, et al. 2008. Clin. Immunol. 127:78. 3. Tsuboi Y, et al. 2007. Clin. Immunol. 124:221. 4. Zhu C, et al. 2005. Nat. Immunol. 6:1245. 5. Dunphy JL, et al. 2002. J. Biol. Chem. 277:14916.\u003cbr\u003e\nGene ID: 16859\u003cbr\u003e\nUniProt: View information about Galectin-9 on UniProt.org\u003cbr\u003e\nClone: 108A2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lgals9, Gal-9, Ecalectin\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860777685161,"sku":"137910","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-137910","provider":"Iright","version":"1.0","type":"link"}