{"product_id":"biolegend-140703","title":"Biolegend, 140703, PE anti-mouse TCR Vβ13 Antibody, 25μg","description":"\u003cp\u003eVβ13 T cell receptor (TCR Vβ13) is a variant of TCR β chain that along with TCR α chain forms the TCR heterodimer. In association with the CD3 complex, TCR α\/β is responsible for antigen recognition in the MHC-Peptide complex and initiation of T cell-mediated immune responses. The most frequently β chains found in the immune response to myelin basic protein (MBP) in B10.PL mice are Vβ13 and Vβ8.2.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: in vitro blocking of antigen-induced proliferation of Vβ13+ T cells 1 and in vivo depletion of Vβ13+ T cells1.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Zaller DM, et al. 1990. J. Exp. Med. 171:1943. (Block)\u003cbr\u003e\nProduct Citations: Vella JL, et al. 2021. Life Sci Alliance. 4:. PubMed\u003cbr\u003e\nRRID: AB_10645512 (BioLegend Cat. No. 140703) AB_10639945 (BioLegend Cat. No. 140704)\u003cbr\u003e\nStructure: Member of the immunoglobulin superfamily, Vβ13 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer.\u003cbr\u003e\nDistribution: Expressed on a subset of TCR αβ+ T cells.\u003cbr\u003e\nFunction: Recognition of peptides presented by the MHC molecules, responsible for T cell mediated immune responses.\u003cbr\u003e\nLigand\/Receptor: MHC-Peptide complex\u003cbr\u003e\nCell Type: T cells\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology\u003cbr\u003e\nMolecular Family: TCRs\u003cbr\u003e\nAntigen References: 1. Zaller DM, et al. 1990. J. Exp. Med. 171:1943. 2. Gentile F, et al. 2004. Immunology 112:13. 3. Lode HN, et al. 1999. P. Natl. Acad. Sci. USA 96:8591.\u003cbr\u003e\nGene ID: 21577\u003cbr\u003e\nUniProt: View information about TCR Vbeta13 on UniProt.org\u003cbr\u003e\nClone: MR12-4\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Vβ13 T-cell receptor, T cell receptor beta 13\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866153177257,"sku":"140703","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-140703","provider":"Iright","version":"1.0","type":"link"}