{"product_id":"biolegend-143004","title":"Biolegend, 143004, PE anti-mouse CD160 Antibody, 100μg","description":"\u003cp\u003eCD160, also known as BY55, is a 27 kD glycoprotein and member of the Ig superfamily. It is anchored to the cell membrane through glycosylphosphatidylinositol (GPI) and forms disulfide-linked multimers. A soluble form of CD160 is secreted by activated CD8 + T cells. Expressed by NK, NKT, γ\/δ T cells, intestinal intraepithelial T cells and a subset of memory CD8 + T cells, CD160 binds both classical and non-classical MHC class I molecules. It is also a ligand for HVEM. CD160 enhances proliferation of activated CD8 + T cells and triggers cell cytotoxicity in NK cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Soluble His-Tag mouse CD160\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Tsujimura K, et al. 2006. Immunol. Lett. 106:48. (FC)\u003cbr\u003e\nProduct Citations: Wu J et al. 2017. Immunity. 47(6):1114-1128 . PubMed Hudson WH, et al. 2020. Immunity. 51(6):1043-1058.e4.. PubMed Flommersfeld S, et al. 2021. Immunity. :. PubMed Beltra JC, et al. 2020. Immunity. 52(5):825-841. PubMed RY H, et al. 2016. Oncoimmunology. 6:e1249561. PubMed\u003cbr\u003e\nRRID: AB_10960740 (BioLegend Cat. No. 143003) AB_10960743 (BioLegend Cat. No. 143004)\u003cbr\u003e\nStructure: Membrane glycoprotein, member of the Ig superfamily, 27 kD, glycosylphosphatidylinositol (GPI)-anchored, forms disulfide-linked multimers on the cell surface\u003cbr\u003e\nDistribution: NK, NKT, γ\/δT cells, intestinal intraepithelial T cells, subset of memory CD8+ T cells\u003cbr\u003e\nFunction: Enhances proliferation of activated CD8+ T cells, triggers cell cytotoxicity in NK cells\u003cbr\u003e\nLigand\/Receptor: Classical and non-classical MHC-class I molecules, HVEM\u003cbr\u003e\nCell Type: NK cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity, Costimulatory Molecules\u003cbr\u003e\nMolecular Family: CD Molecules, MHC Antigens, TCRs\u003cbr\u003e\nAntigen References: 1. Shui JW, et al. 2011. J. Leukoc. Biol. 89:517. 2. Del Rio ML, et al. 2010. J. Leukoc. Biol. 87:223. 3. Cai G and Freeman GJ. 2009. Immunol. Rev. 229:244.\u003cbr\u003e\nGene ID: 54215\u003cbr\u003e\nUniProt: View information about CD160 on UniProt.org\u003cbr\u003e\nClone: 7H1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BY55, NK1, NK28\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862489583785,"sku":"143004","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-143004","provider":"Iright","version":"1.0","type":"link"}