{"product_id":"biolegend-143406","title":"Biolegend, 143406, APC anti-mouse CD371 (CLEC12A) Antibody, 100μg","description":"\u003cp\u003eCD371 (CLEC12A), also known as DCAL-2, MICL or CLL-1, is a 30 kD type II transmembrane protein with extracellular C-type lectin domains, belonging to the C-type lectin family.  Its cytoplasmic ITIM motif modulates signaling cascades and is involved in phosphorylation of tyrosine residues in MAP kinases. Mouse CLEC12A is expressed on CD8 + dendritic cells (DCs), a proportion of CD8 - dendritc cells, plasmacytoid DCs, monoctyes, macrophages, granulocytes, and B cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: CHO expressing mouse CLEC12A\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Yashchenko A, et al. 2023. Front Immunol. 14:1082078. PubMed Bravo DD, et al. 2023. J Immunol. 1166:210. PubMed Brown CC, et al. 2020. Cell. 179(4):846-863.e24.. PubMed Scheyltjens I, et al. 2022. Nat Protoc. 17:2354. PubMed\u003cbr\u003e\nRRID: AB_2564264 (BioLegend Cat. No. 143405) AB_2564265 (BioLegend Cat. No. 143406)\u003cbr\u003e\nStructure: Type II C-type lectin family member, 265 aa, 30.7 kD\u003cbr\u003e\nDistribution: CD8+ dendritic cells (DCs), a proportion of CD8- dendritic cells, plasmacytoid DCs, monocytes, macrophages, granulocytes, B cells\u003cbr\u003e\nFunction: Negative regulator of granuocyte and monocyte function\u003cbr\u003e\nInteraction: PTPN6 and PTPN11\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Embryonic Stem Cells, Granulocytes, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology, Innate Immunity, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Lahoud MH, et al. 2009. J. Immunol. 182:7587. 2. Chen CH, et al. 2006. Blood 107:1459. 3. Marshall AS, et al. 2004. J. Biol. Chem. 279:14792.\u003cbr\u003e\nGene ID: 232413\u003cbr\u003e\nUniProt: View information about CD371 on UniProt.org\u003cbr\u003e\nClone: 5D3\/CLEC12A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLL1, MICL, CLL-1, DCAL-2, C-type lectin domain family 12 member A, CD371\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864165109929,"sku":"143406","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-143406","provider":"Iright","version":"1.0","type":"link"}