{"product_id":"biolegend-144203","title":"Biolegend, 144203, PE anti-mouse\/human CD207 (Langerin) Antibody, 25μg","description":"\u003cp\u003eCD207, also known as langerin, is a 40 kD single-pass type II transmembrane protein, member of the C-type lectin family. CD207 is expressed on the cell surface and Birbeck granules (BGs) of Langerhans cells, and subsets of thymic and splenic dendritic cells. Its ligands are mannose, n -acetylglucosamine, fucose, and sulfated glycans. Langerin is involved in the antigen processing pathway through capture and internalization of its ligands.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse, Human\u003cbr\u003e\nReported Reactivity: Cynomolgus, Rabbit, Pig\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Langerin extracellular domain-Fc fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality testedIHC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Huang T, et al. 2023. Cell Death Dis. 14:354. PubMed Zhou H, et al. 2022. EMBO Rep. 23:e53791. PubMed Hardman CS, et al. 2022. Nat Commun. 13:7535. PubMed Tatsumi N, et al. 2022. STAR Protoc. 3:101845. PubMed Wong Fok Lung T, et al. 2020. Nat Microbiol. 141:5. PubMed Li Z, et al. 2021. Immunology. 163:105. PubMed Park S, et al. 2021. Nat Cell Biol. 23:476. PubMed Samarchith P Kurup et al. 2019. Cell host \u0026amp; microbe. 25(4):565-577 . PubMed Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed Acker KP, et al. 2019. iScience. 19:281. PubMed Zhang X, et al. 2022. JCI Insight. 7:. PubMed Sheng J, et al. 2021. eLife. 10:00. PubMed Stotesbury C, et al. 2020. Aging Cell. 19:e13170. PubMed Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed Chen R, et al. 2021. Front Oncol. 11:743050. PubMed\u003cbr\u003e\nRRID: AB_2561498 (BioLegend Cat. No. 144203) AB_2561499 (BioLegend Cat. No. 144204)\u003cbr\u003e\nStructure: Single-pass type II transmembrane protein, 40 kD, one C-type lectin domain, homotrimer\u003cbr\u003e\nDistribution: Langerhans cells, subsets of thymic and splenic dendritic cells\u003cbr\u003e\nFunction: Antigen uptake, antigen processing\u003cbr\u003e\nLigand\/Receptor: Mannose, n-acetylglucosamine, fucose, sulfated glycans\u003cbr\u003e\nCell Type: Dendritic cells, Langerhans cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Romani N, et al. 2012. Curr. Top. Microbiol. Immunol. 351:113. 2. Kaplan DH. 2010. Trends Immunol. 31:446. 3. Clausen BE and Kel JM. 2010. Immunol. Cell. Biol. 88:351. 4. Merad M, et al. 2008. Nat. Rev. Immunol. 8:935.\u003cbr\u003e\nGene ID: 24627850489\u003cbr\u003e\nUniProt: View information about CD207 on UniProt.org\u003cbr\u003e\nClone: 4C7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CLEC4K\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862413496489,"sku":"144203","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-144203","provider":"Iright","version":"1.0","type":"link"}