{"product_id":"biolegend-148003","title":"Biolegend, 148003, PE anti-mouse CD300c\/d Antibody, 25μg","description":"\u003cp\u003eCD300 receptors are a group of type I transmembrane proteins, which belong to the Ig superfamily. In mice, nine members have been reported with different nomenclature systems, such as myeloid-associated Ig-like receptor (MAIR), leukocyte mono-Ig-like receptor (LMIR), DC-derived Ig-like receptor (DIgR), and CMRF-35-like molecule (CLM). The CD300 molecules act as either activating or inhibitory receptors through interactions with adaptor molecules, such as PAD12, DAP10, and FcRγ. Despite sharing high homology with CD300a, CD300c (LMIR-II) does not share its inhibitory function. CD300c has been found to activate a variety of cell types and induce proinflammatory molecule production. CD300d may be involved with the regulation\/formation of CD300 complexes on the cell surface.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: MAIR-II transfected Ba\/F3\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Additional reported applications (for the relevant formats) include: Western blotting1.\u003cbr\u003e\nRRID: AB_2563674 (BioLegend Cat. No. 148003) AB_2563675 (BioLegend Cat. No. 148004)\u003cbr\u003e\nStructure: Type I transmemrane protein, Ig superfamily\u003cbr\u003e\nDistribution: B cell subsets, macrophages, dendritic cells\u003cbr\u003e\nInteraction: DAP12, DAP10, FcRγ\u003cbr\u003e\nLigand\/Receptor: Phosphatidylserine\u003cbr\u003e\nCell Type: B cells, Macrophages, Dendritic cells\u003cbr\u003e\nBiology Area: Immunology, Innate Immunity\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: 1. Yotsumoto K, et al. 2003. J. Exp. Med. 198:223.2. Martinez-Barriocanal A, et al. 2010. J. Biol. Chem. 285:41781.3. Borrego F. 2013. Blood. 121:1951.4. Lankry D, et al. 2013. Eur. J. Immunol. 43:2151.\u003cbr\u003e\nGene ID: 387565140497\u003cbr\u003e\nUniProt: View information about CD300c\/d on UniProt.org\u003cbr\u003e\nClone: TX52\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD300c\/d, MAIR-II, LMIR-II, CLM-4, DIgR1, CLM-6\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864059793577,"sku":"148003","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-148003","provider":"Iright","version":"1.0","type":"link"}