{"product_id":"biolegend-148603","title":"Biolegend, 148603, PE anti-mouse CD282 (TLR2) Antibody, 25μg","description":"\u003cp\u003eCD282, also known as TLR2, is an 89 kD, type I transmembrane protein, with 14 leucine-rich repeats (LRR) in the extracellular region and one toll\/IL-1R (TIR) domain in the intracellular region. TLR2 is mainly expressed on monocytes, macrophages, dendritic cells, granulocytes, and endothelial and epithelial cells. TLR2 associates with TLR1 and TLR6, and mediates the innate immune response against several components of Gram-positive bacteria, such as peptidoglycan, lipoteichoic acid (LTA), lipoarabinomanan, and lipoproteins as well as different LPS from certain Gram-negative bacteria, yeast, spirochetes, and fungi.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse TLR2-transfected Ba\/F3 cells.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: 1. Shibata T, et al. 2012. Int. Immunol. 24:613. (FC)\u003cbr\u003e\nProduct Citations: Michela Miani et al. 2018. Cell metabolism. 28(4):557-572 . PubMed Ji Y, et al. 2023. Nat Cell Biol. 25:726. PubMed Takayanagi Y, et al. 2020. J Clin Med. 9:00. PubMed Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed Lax N, et al. 2020. J Neuroinflammation. 17:55. PubMed Di Lorenzo A, et al. 2022. Oncoimmunology. 11:2086752. PubMed Lee GR, et al. 2021. JCI Insight. 6:. PubMed\u003cbr\u003e\nRRID: AB_2564119 (BioLegend Cat. No. 148603) AB_2564120 (BioLegend Cat. No. 148604)\u003cbr\u003e\nStructure: 89 kD type I transmembrane protein with 14 leucine-rich repeats (LRR) on its extracellular region and one toll\/IL-1R (TIR) domain on its intracellular region.\u003cbr\u003e\nDistribution: Monocytes, macrophages, dendritic cells, granulocytes, endothelial cells, epithelial cells.\u003cbr\u003e\nFunction: Activates innate host defense against a diverse set of pathogens.\u003cbr\u003e\nInteraction: TLR1, TLR6.\u003cbr\u003e\nLigand\/Receptor: Microbial lipoproteins, peptidoglycans, lipoteichoic acid.\u003cbr\u003e\nCell Type: Dendritic cells, Endothelial cells, Epithelial cells, Granulocytes, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules, Toll Like Receptors\u003cbr\u003e\nAntigen References: 1. Du B, et al. 2013. J. Biol. Chem. 288:15131. 2. Zivkovic A, et al. 2011. J. Immunol. 186:1608. 3. Okun E, et al. 2010. J. Neurochem. 114:462. 4. Kim S, et al. 2009. Nature. 457:102.\u003cbr\u003e\nGene ID: 24088\u003cbr\u003e\nUniProt: View information about CD282 on UniProt.org\u003cbr\u003e\nClone: CB225\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TLR-2, mTLR2, Ly105\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862962491561,"sku":"148603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-148603","provider":"Iright","version":"1.0","type":"link"}