{"product_id":"biolegend-149702","title":"Biolegend, 149702, Purified anti-mouse Granzyme A Antibody, 100μg","description":"\u003cp\u003eGranzyme A is a serine protease that is similar to Granzyme B. However, unlike granzyme B, granzyme A is a homodimer. It is expressed in cytotoxic T cells and natural killer cells (NK), but is not essential for induction of apoptosis or DNA fragmentation. Cell death induced by granzyme A is slower and morphologically different than the cell death induced by granzyme B. It plays a crucial role in infection-mediated inflammation as well as immunological responses against viruses, bacteria, and tumor cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Full length recombinant granzyme A of mouse origin.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Fehniger TA, et al. 2007. Immunity 26:798. (ICFC)\u003cbr\u003e\nProduct Citations: Anthony SM, et al. 2021. eLife. 10:00. PubMed Yang M, et al. 2020. Oncoimmunology. 9:1708064. PubMed\u003cbr\u003e\nRRID: AB_2565308 (BioLegend Cat. No. 149702)\u003cbr\u003e\nStructure: 29 kD, Homodimer, Serine protease\u003cbr\u003e\nDistribution: Cytotoxic T cells and natural killer cells (NK); low on granulocytes, B cells, and activated dendritic cells (DCs).\u003cbr\u003e\nFunction: Induction of cell death and apoptosis.\u003cbr\u003e\nCell Type: T cells, NK cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience\u003cbr\u003e\nMolecular Family: Proteases, Enzymes and Regulators\u003cbr\u003e\nAntigen References: 1. Susanto O, et al. 2013. Cell Death Differ. 20:1183. 2. Ebnet K, et al. 1995. EMBO J. 14:4230. 3. Jenne DE, et al. 1988. Immunol. Rev. 103:53.\u003cbr\u003e\nGene ID: 14938\u003cbr\u003e\nUniProt: View information about Granzyme A on UniProt.org\u003cbr\u003e\nClone: 3G8.5\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Hf, SE1, TSP1, Ctla3, TSP-1, Ctla-3, AW494114\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862399799465,"sku":"149702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-149702","provider":"Iright","version":"1.0","type":"link"}