{"product_id":"biolegend-150603","title":"Biolegend, 150603, Alexa Fluor® 647 anti-mouse CD192 (CCR2) Antibody, 25μg","description":"\u003cp\u003eCD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CCR2 transfectants.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm \/ 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Christian DA, et al. 2022. Sci Immunol. 7:eabq7432. PubMed Mansouri N, et al. 2019. JCI Insight. 4:e128060. PubMed Sun G et al. 2018. Cell reports. 25(13):3786-3799 . PubMed Mariani SA, et al. 2019. Immunity. 50:1439. PubMed Linde N, et al. 2018. Nat Commun. 9:21. PubMed Oladiran O, et al. 2021. J Neuroinflammation. 77:18. PubMed Pascual–García M, et al. 2019. Nat Commun. 10:2416. PubMed Guo P, et al. 2021. J Immunol. 207:408. PubMed Blagih J, et al. 2020. Cell Rep. 30:481. PubMed Fan A, et al. 2020. J Neuroinflammation. 17:179. PubMed Wu B, et al. 2020. Int J Biol Sci. 1.132638889. PubMed Barbet G, et al. 2018. Immunity. 48:584. PubMed Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed Peruzzotti-Jametti L, et al. 2018. Cell Stem Cell. 22:355. PubMed Chen KE, et al. 2021. J Neuroinflammation. 18:140. PubMed Oladiran O, et al. 2021. Front Immunol. 12:720733. PubMed Kubli SP, et al. 2019. Nat Commun. 10:2678. PubMed van Ingen E, et al. 2021. Mol Ther Nucleic Acids. 26:1228. PubMed\u003cbr\u003e\nRRID: AB_2566139 (BioLegend Cat. No. 150603) AB_2566140 (BioLegend Cat. No. 150604)\u003cbr\u003e\nStructure: G-protein-coupled receptor, 7-transmembrane protein, 42 kD.\u003cbr\u003e\nDistribution: Monocytes\/macrophages and basophils.\u003cbr\u003e\nFunction: Mediator of monocyte chemotaxis and bone marrow homeostasis.\u003cbr\u003e\nLigand\/Receptor: MCP-1, Ccl2, Ccl7, and Ccl13.\u003cbr\u003e\nCell Type: Basophils, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Mack M, et al. 2001. J. Immunol. 166:4697. 2. Dutta P, et al. 2015. Cell Stem Cell. 16:477. 3. Li L, et al. 2008. Kidney Int. 74:1526.\u003cbr\u003e\nGene ID: 12772\u003cbr\u003e\nUniProt: View information about CD192 on UniProt.org\u003cbr\u003e\nClone: SA203G11\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Ccr2, Ckr2, Ccr2a, Ccr2b\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866283790505,"sku":"150603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-150603","provider":"Iright","version":"1.0","type":"link"}