{"product_id":"biolegend-151104","title":"Biolegend, 151104, PE anti-mouse CD186 (CXCR6) Antibody, 100μg","description":"\u003cp\u003eCD186, or CXCR6, is a 39 kD G-protein coupled chemokine receptor with seven transmembrane-spanning regions. Its ligand is CXCL16. It is expressed on different T cell subsets and is upregulated in activated T cells. Expression of CXCR6 is correlated with increased inflammatory responses and seems to contribute to liver fibrosis.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: mCXCR6-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed Sandu I, et al. 2020. Nat Commun. 11:4454. PubMed Scherer S, et al. 2023. Nat Immunol. 24:501. PubMed Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed Misumi I et al. 2019. Cell Rep. 27(2):514-524 . PubMed Sugimoto C, et al. 2022. Elife. 11:. PubMed Zhuang Z, et al. 2021. J Exp Med. 218:00:00. PubMed Flommersfeld S, et al. 2021. Immunity. :. PubMed Prosser A, et al. 2021. Cell Reports. 35(7):109141. PubMed Wang B, et al. 2021. J Immunother Cancer. 9:. PubMed Borges da Silva H, et al. 2020. Immunity. 53(1):158-171.e6. PubMed Srivastava S, et al. 2020. Cancer Cell. 39(2):193-208.e10. PubMed Rosen SF, et al. 2022. Genome Med. 14:108. PubMed Prosser A, et al. 2021. STAR Protoc. 2:100810. PubMed\u003cbr\u003e\nRRID: AB_2566545 (BioLegend Cat. No. 151103) AB_2566546 (BioLegend Cat. No. 151104)\u003cbr\u003e\nStructure: G-protein coupled receptor 1 family.\u003cbr\u003e\nDistribution: T cells and natural killer T (NKT) cells.\u003cbr\u003e\nFunction: Chemotaxis and the development of T cells.\u003cbr\u003e\nLigand\/Receptor: CXCL16.\u003cbr\u003e\nCell Type: NKT cells, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Kim CH, et al. 2001. J. Clin. Invest. 107:595. 2. Heesch K, et al. 2014. PLoS One. 9:5. 3. Wehr A, et al. 2013. J. Immunol. 190:5226.\u003cbr\u003e\nGene ID: 80901\u003cbr\u003e\nUniProt: View information about CD186 on UniProt.org\u003cbr\u003e\nClone: SA051D1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CXCR6, Chemokine (C-X-C motif) receptor 6, BONZO, STRL33, chemokine receptor 6, CD 186, CXC-R6, CXCR-6, C-X-C chemokine receptor type 6\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866282283177,"sku":"151104","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-151104","provider":"Iright","version":"1.0","type":"link"}