{"product_id":"biolegend-152507","title":"Biolegend, 152507, PE anti-mouse CD191 (CCR1) Antibody, 25μg","description":"\u003cp\u003eCD191, also known as CCR1, is a seven transmembrane G protein coupled receptor. It is involved in protecting the host from inflammatory responses and viral\/parasite invasion, ligands include macrophage inflammatory protein 1 alpha (MIP-1 alpha, ), regulated on activation normal T expressed and secreted protein (RANTES, CCL5), monocyte chemoattractant protein 3 (MCP-3, CCL7), and myeloid progenitor inhibitory factor-1 (MPIF-1, CCL23).\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse CCR1-transfectants.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Yari S, et al. 2023. Inflamm Regen. 43:18. PubMed Palakurthi B, et al. 2023. Nat Commun. 14:2109. PubMed Kastenschmidt JM, et al. 2021. Cell Rep. 35:108997. PubMed\u003cbr\u003e\nRRID: AB_2800688 (BioLegend Cat. No. 152507) AB_2800689 (BioLegend Cat. No. 152508)\u003cbr\u003e\nStructure: 41KD, seven transmembrane protein.\u003cbr\u003e\nDistribution: Macrophages, monocytes, neutrophils and eosinophils.\u003cbr\u003e\nFunction: Regulating migration of cells in response to CCL3, CCL5, CCL7 and CCL23.\u003cbr\u003e\nLigand\/Receptor: CCL3, CCL5, CCL7 and CCL23.\u003cbr\u003e\nCell Type: Eosinophils, Macrophages, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Lionakis MS, et al. 2012. PLoS Pathog. 8:e1002865. 2. Gilliland CT, et al. 2013. J. Biol. Chem. 288:32194. 3. Gong X, et al. 1997. J. Biol. Chem. 272:11682. 4. Daugherty BL, Springer MS. 1997. Genomics. 41:294. 5. Pakianathan DR, et al. 1997. Biochemistry 36:9642.\u003cbr\u003e\nGene ID: 12768\u003cbr\u003e\nUniProt: View information about CD191 on UniProt.org\u003cbr\u003e\nClone: S15040E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CKR1, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866215960745,"sku":"152507","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-152507","provider":"Iright","version":"1.0","type":"link"}