{"product_id":"biolegend-152608","title":"Biolegend, 152608, PE anti-mouse CD95 (Fas) Antibody, 100μg","description":"\u003cp\u003eCD95, also known as Fas, is an approximately 45 kD type I transmembrane protein belonging to the TNFR superfamily (TNFRSF6). The expression of CD95 has been described in various organs, such as  thymus, spleen, liver, heart, lung and ovary. Upon ligand (FasL) binding, CD95 forms the death-inducing signaling complex (DISC) intracellularly and induce apoptosis of the cell. CD95-induced apoptosis plays important roles in development, as well as in maintining peripheral tolerance of the immune system.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Mouse Fas Transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Du J, et al. 2022. Sci Immunol. 7:eabo5407. PubMed Yang Y, et al. 2023. Cancers (Basel). 15:. PubMed Tai W, et al. 2023. Nat Commun. 14:2962. PubMed Zander R, et al. 2022. Immunity. 55:475. PubMed Wight AE, et al. 2022. Proc Natl Acad Sci U S A. 119:e2200757119. PubMed Trittel S, et al. 2019. Sci Rep. 9:16362. PubMed Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed Kim CJ, et al. 2018. Immunity. 49:1034. PubMed Woodruff MC et al. 2018. Cell reports. 25(2):321-327 . PubMed Pobezinskaya EL et al. 2019. Front Immunol. 1.079861111 . PubMed Waide ML, et al. 2020. Cell Rep. 33:108503. PubMed Wang J, et al. 2018. Front Immunol. 9:371. PubMed Zhang YN, et al. 2020. EBioMedicine. 56:102819. PubMed Beloor J et al. 2018. Cell host \u0026amp; microbe. 23(4):549-556 . PubMed Kang X, et al. 2022. J Immunol Res. 2022:8118577. PubMed Mandal RK, et al. 2021. Cell Reports. 35(6):109094. PubMed Lazarian G, et al. 2021. Cancer Cell. 39(3):380-393.e8. PubMed Huang WC, et al. 2020. Adv Mater. 32:e2005637. PubMed Dheilly E, et al. 2020. Cancer Cell. 37(5):674-689. PubMed Dumitrescu M, et al. 2020. Int J Mol Sci. 21:00. PubMed Chen S, et al. 2018. Nat Commun. 9:5298. PubMed Li X, et al. 2021. Front Immunol. 12:779560. PubMed\u003cbr\u003e\nRRID: AB_2632903 (BioLegend Cat. No. 152607) AB_2632902 (BioLegend Cat. No. 152608)\u003cbr\u003e\nStructure: CD95 (Fas) is an approximately 45 kD type I transmembrane protein; cystiene-rich domain, death domain.\u003cbr\u003e\nDistribution: Thymus, spleen, liver, heart, lung, and ovary.\u003cbr\u003e\nFunction: Induction of apoptosis.\u003cbr\u003e\nInteraction: Caspase 8, caspase 10, CFLAR, FADD, PDCD6, SUMO1, and TNFRSF6.\u003cbr\u003e\nLigand\/Receptor: FasL\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Ogasawara J, et al. 1995. J Exp Med. 181:485-91. Ogasawara J, et al. 1993. Nature. 364:806-9. Nishimura Y, et al. 1995. J Immunol. 154:4395-403.\u003cbr\u003e\nGene ID: 14102\u003cbr\u003e\nUniProt: View information about CD95 on UniProt.org\u003cbr\u003e\nClone: SA367H8\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fas, ALPS1A, APO-1, APT1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866292637865,"sku":"152608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-152608","provider":"Iright","version":"1.0","type":"link"}