{"product_id":"biolegend-153304","title":"Biolegend, 153304, PE anti-mouse Folate Receptor β (FR-β) Antibody, 100μg","description":"\u003cp\u003eFolate receptor beta (FR-β) is a member of a family of folate binding receptors that have diverse structural identities but mediate transport of folates into cells. FR-β is a GPI-anchored protein with high affinity for folic acid. It is postulated that this receptor function as folate scavengers when folate supply is low or rapid cell growth requires elevated uptake of folate for methylation reactions including DNA biosynthesis. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse Folate receptor β transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Nagai T, et al. 2009. Cancer Immunol Immunother. 1577-86.\u003cbr\u003e\nProduct Citations: Lu JC, et al. 2024. Nat Commun. 621:15. PubMed Utz SG, et al. 2020. Cell. 181(3):557-573. PubMed Scheyltjens I, et al. 2022. Nat Protoc. 17:2354. PubMed\u003cbr\u003e\nRRID: AB_2721343 (BioLegend Cat. No. 153303) AB_2721344 (BioLegend Cat. No. 153304)\u003cbr\u003e\nStructure: 30 kD, seven disulfide bonds\u003cbr\u003e\nDistribution: Placenta, monocytes, tissue resident macrophages\u003cbr\u003e\nFunction: Transport of folate into cells\u003cbr\u003e\nLigand\/Receptor: Folic Acid\u003cbr\u003e\nCell Type: Macrophages, Monocytes\u003cbr\u003e\nAntigen References: 1. Elwood PC, 1989, J Biol Chem, 264:14893. 2. Shen F, et al, 1994, Biochemistry, 8;33:1209. 3. Yi YS, 2016, Immune Netw,16:337.\u003cbr\u003e\nGene ID: 14276\u003cbr\u003e\nUniProt: View information about Folate Receptor beta on UniProt.org\u003cbr\u003e\nClone: 10\/FR2\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: FR-β\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860769755305,"sku":"153304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-153304","provider":"Iright","version":"1.0","type":"link"}