{"product_id":"biolegend-154508","title":"Biolegend, 154508, PE\/Cyanine7 anti-mouse β2-microglobulin Antibody, 100μg","description":"\u003cp\u003eBeta 2-microglobulin (β2M) is a 12 kDa, Ig like, non-membrane-anchored glycoprotein. It non-covalently associates with MHC class I heavy chain and some Class I-like molecules and serves as the light chain. In association with MHC class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role in stabilizing MHC class I complexes for antigen presentation. In humans, circulating β2M levels are elevated in autoimmune\/inflammatory disorders, viral infections, and glomerular filtration disorders.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant Mouse B2M\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is = 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Hum NR, et al. 2020. Cancers (Basel). :12. PubMed\u003cbr\u003e\nRRID: AB_2728212 (BioLegend Cat. No. 154507) AB_2728213 (BioLegend Cat. No. 154508)\u003cbr\u003e\nStructure: 12 kD, Ig like glycoprotein\u003cbr\u003e\nDistribution: Leukocytes, platelets, endothelial cells, epithelial cells\u003cbr\u003e\nFunction: Component of MHC class I complex\u003cbr\u003e\nLigand\/Receptor: TCR (through MHC class I)\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Leukocytes, Platelets\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: MHC Antigens\u003cbr\u003e\nAntigen References: Bernier GM, 1980, ox Sang, 38:323. Williams A, et al, 2002, Tissue Antigens, 59:3. Williams DB, et al, 1989, J. Immunol, 142:2796. Benoit LA, et al. 2007, J Immunol, 179:3588.\u003cbr\u003e\nGene ID: 12010\u003cbr\u003e\nUniProt: View information about beta2-microglobulin on UniProt.org\u003cbr\u003e\nClone: A16041A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Ly-m11, beta2m, beta2-m\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864393535657,"sku":"154508","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-154508","provider":"Iright","version":"1.0","type":"link"}