{"product_id":"biolegend-155305","title":"Biolegend, 155305, APC anti-mouse CD163 Antibody, 25μg","description":"\u003cp\u003eCD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI\/61, M130, RM3\/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)\/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem\/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant mouse CD163 extracellular domain\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nProduct Citations: Lee CY, et al. 2023. Viruses. 15:. PubMed Poh AR, et al. 2022. Sci Adv. 8:eabl7882. PubMed Harb H, et al. 2021. Immunity. 54(6):1186-1199.e7. PubMed Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed Jiang H, et al. 2022. Cell Death Dis. 13:183. PubMed\u003cbr\u003e\nRRID: AB_2814059 (BioLegend Cat. No. 155305) AB_2814060 (BioLegend Cat. No. 155306)\u003cbr\u003e\nStructure: Type 1 transmembrane glycoprotein, 134 kD (non-reduced)\/155 kD (reduced) glycoprotein\u003cbr\u003e\nDistribution: Macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem\/progenitor cells\u003cbr\u003e\nFunction: Binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 93671\u003cbr\u003e\nUniProt: View information about CD163 on UniProt.org\u003cbr\u003e\nClone: S15049I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: M130, MM130, SCARI1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866219827369,"sku":"155305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-155305","provider":"Iright","version":"1.0","type":"link"}