{"product_id":"biolegend-159005","title":"Biolegend, 159005, PE\/Cyanine7 anti-mouse IL-27Rα Antibody, 25μg","description":"\u003cp\u003e69 kD glycosylated transmembrane subunit of IL-27 receptor complex consisting of IL27Ra (WSX-1, TCCR) and gp130 (CD130). Expressed on T cells, monocytes, and neutrophils and aside from its effect on innate immunity, is involved in dampening the extent of Th1 immune response post infection. Activity levels of  INF-γ and IL-17 producing T cells are regulated through this receptor which relays signal through Jak-STAT pathway.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse IL-27Rα transfectant\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2910326 (BioLegend Cat. No. 159005) AB_2910326 (BioLegend Cat. No. 159006)\u003cbr\u003e\nDistribution: IL27Ra is expressed by T cells, monocytes, and neutrophils.\u003cbr\u003e\nLigand\/Receptor: IL27Ra combines with gp130 to form a receptor complex whose activation by IL-27 leads to differing pathway-dependent effector activities.\u003cbr\u003e\nCell Type: Monocytes, Neutrophils, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: Takeda A, et al. 2003. J Immunol. 170:4886-90. Yoshida H \u0026amp; Hunter CA. 2015. Annu Rev Immunol. 33:417-43. Iwasaki Y, et al. 2015. Int J Mol Sci. 16:2851-63.\u003cbr\u003e\nGene ID: 50931\u003cbr\u003e\nUniProt: View information about IL-27Ralpha on UniProt.org\u003cbr\u003e\nClone: W16125D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: interleukin27 receptor alpha, IL27ra, IL-27Ra, TCCR, WSX-1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866304565417,"sku":"159005","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-159005","provider":"Iright","version":"1.0","type":"link"}